Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Khorchid, A.; Ikura, M.
    Bacterial histidine kinase as signal sensor and transducer (2006), Int. J. Biochem. Cell Biol., 38, 307-312.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.13.3 medicine significance in pathological virulence of Salmonella enterica, seductive target for anti-bacterial therapeutic development Salmonella enterica
2.7.13.3 additional information 15 of the 30 known Escherichia coli histidine kinases contain a single HAMP domain, has an important role in signal transduction Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
2.7.13.3 additional information mutations within the linker HAMP domain block the osmosensing function of EnvZ Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.13.3 inner membrane EnvZ with a N-terminal cytoplasmic tail (residues 1-15), two transmembrane domains (residues 16-34 and residues 163-179) flanking a periplasmic domain (residues 48-162), and a cytoplasmic domain (residues 180-450). The cytoplasmic domain can be further dissected into a linker or HAMP domain (residues 180-222), domain A (dimerization and histidine containing domain, residues 223-289) and domain B (catalysis assisting and ATP binding domain, residues 290-450), UhpB contains eight transmembrane segments Escherichia coli
-
-
2.7.13.3 membrane FixL contains four transmembrane segments Sinorhizobium meliloti 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.13.3 Escherichia coli
-
-
-
2.7.13.3 Salmonella enterica
-
-
-
2.7.13.3 Sinorhizobium meliloti
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.13.3 ENVZ
-
 Escherichia coli
2.7.13.3 FixL
-
 Sinorhizobium meliloti
2.7.13.3 histidine kinase
-
 Sinorhizobium meliloti
2.7.13.3 histidine kinase
-
 Escherichia coli
2.7.13.3 histidine kinase
-
 Salmonella enterica
2.7.13.3 UhpB
-
 Escherichia coli