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Literature summary extracted from

  • Wanyiri, J.W.; OConnor, R.; Allison, G.; Kim, K.; Kane, A.; Qiu, J.; Plaut, A.G.; Ward, H.D.
    Proteolytic processing of the Cryptosporidium glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity (2007), Infect. Immun., 75, 184-192.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.75 Ca2+ parasite expresses a Ca2+ dependent, furin-like protease activity Cryptosporidium parvum

Application

EC Number Application Comment Organism
3.4.21.75 medicine furin-like protease activity may be involved in mediating host-parasite interactions. Inhibition of infection is due to an effect on the parasite-derived furin activity rather than the host cell furin Cryptosporidium parvum

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.75 1,10-phenanthroline
-
Cryptosporidium parvum
3.4.21.75 4-(2-aminoethyl)benzenesulphonyl fluoride
-
Cryptosporidium parvum
3.4.21.75 decanoyl-Arg-Val-Lys-Arg-chloromethylketone most inhibitory, inhibits Cryptosporidium parvum infection of HCT-8 cells in a dose-dependent manner, with ca. 50% inhibition occurring at a concentration of 0.01 mM Cryptosporidium parvum
3.4.21.75 EDTA 97% inhibition, Ca2+ can reverse the inhibitory effect Cryptosporidium parvum
3.4.21.75 EDTA completely inhibits Homo sapiens
3.4.21.75 EGTA
-
Cryptosporidium parvum
3.4.21.75 Glu-Gly-Arg-chloromethylketone poor inhibitor Cryptosporidium parvum
3.4.21.75 leupeptin
-
Cryptosporidium parvum
3.4.21.75 additional information aprotinin has no effect on furin-like protease activity Cryptosporidium parvum
3.4.21.75 N-tosyl-L-lysine chloromethyl ketone
-
Cryptosporidium parvum
3.4.21.75 Phe-Pro-Arg-chloromethylketone poor inhibitor Cryptosporidium parvum
3.4.21.75 phenylmethylsulfonyl fluoride
-
Cryptosporidium parvum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.75 0.01517
-
t-butyloxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin
-
Cryptosporidium parvum

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.75 Cryptosporidium parvum
-
-
-
3.4.21.75 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.75 HCT-8 cell
-
Homo sapiens
-
3.4.21.75 additional information lysate Cryptosporidium parvum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.75 gp40/15 + H2O cleaves recombinant Cryptosporidium parvum and Cryptosporidium hominis gp40/15. Putative furin cleavage site RSRR Homo sapiens gp40 + gp15
-
?
3.4.21.75 gp40/15 + H2O putative furin cleavage site RSRR Cryptosporidium parvum gp40 + gp15
-
?
3.4.21.75 gp40/15 subtype 1e + H2O RSRR sequence is replaced by ISKR, has an alternative furin cleavage site at KSISKR2 Homo sapiens gp40 + gp15
-
?
3.4.21.75 gp40/15 subtype 1e + H2O RSRR sequence is replaced by ISKR, has an alternative furin cleavage site at KSISKR2 Cryptosporidium parvum gp40 + gp15
-
?
3.4.21.75 additional information mutation in the RSRR cleavage site prevents processing of gp40/15 Homo sapiens ?
-
?
3.4.21.75 additional information mutation in the RSRR cleavage site prevents processing of gp40/15 Cryptosporidium parvum ?
-
?
3.4.21.75 t-butyloxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens ?
-
?
3.4.21.75 t-butyloxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Cryptosporidium parvum ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.75 furin-like protease
-
Cryptosporidium parvum
3.4.21.75 subtilisin-like proprotein convertase
-
Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.75 7
-
-
Cryptosporidium parvum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.21.75 4 8
-
Cryptosporidium parvum