Literature summary extracted from

Kato, Y.; Ozawa, S.; Tsukuda, M.; Kubota, E.; Miyazaki, K.; St-Pierre, Y.; Hata, R.
Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma (2007), FEBS J., 274, 3171-3183.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.4.4	additional information	acidic extracellular pH induces enzyme activity both via Ca2+ influx and acidic shingomyelinase	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.4.4	1,2-bis(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl) ester	i.e. BAPTA-AM, chelator of intracellular free calcium, application results in reduction of extracellular pH-induced enzyme activity	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.4	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.4.4	B-16 cell	melanoma cell	Mus musculus	-

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Release 2023.1 (January 2023)