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Literature summary extracted from

  • Drucker, D.J.
    Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action (2007), Diabetes Care, 30, 1335-1343.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 Syrrx106124 acutely lowers blood glucose and enhances glucose-stimulated insulin secretion in wild-type mice and in mice with targeted disruption of single incretin receptors Mus musculus
3.4.14.5 TP8211 acutely lowers blood glucose and enhances glucose-stimulated insulin secretion in wild-type mice and in mice with targeted disruption of single incretin receptors Mus musculus
3.4.14.5 valine pyrrolidide
-
Sus scrofa
3.4.14.5 vildagliptin acutely lowers blood glucose and enhances glucose-stimulated insulin secretion in wild-type mice and in mice with targeted disruption of single incretin receptors Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.14.5 additional information Homo sapiens DPP-4 is an important determinant of incretin inactivation ?
-
?
3.4.14.5 additional information Mus musculus DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior ?
-
?
3.4.14.5 additional information Rattus norvegicus DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Homo sapiens
-
-
-
3.4.14.5 Mus musculus
-
-
-
3.4.14.5 Rattus norvegicus
-
-
-
3.4.14.5 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.5 nose levels of tissue DPP-4 are reduced in nasal tissue of human subjects with chronic rhinosinusitis Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 glucagon-like peptide-1 + H2O
-
Homo sapiens ?
-
?
3.4.14.5 glucagon-like peptide-1 + H2O
-
Sus scrofa ?
-
?
3.4.14.5 glucose-dependent insulinotropic polypeptide + H2O
-
Homo sapiens ?
-
?
3.4.14.5 glucose-dependent insulinotropic polypeptide + H2O
-
Sus scrofa ?
-
?
3.4.14.5 additional information DPP-4 is an important determinant of incretin inactivation Homo sapiens ?
-
?
3.4.14.5 additional information DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior Mus musculus ?
-
?
3.4.14.5 additional information DPP-4 plays a role in the control of immune function, inflammatory responses, and behavior Rattus norvegicus ?
-
?
3.4.14.5 Substance P + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.5 DPP-4
-
Mus musculus
3.4.14.5 DPP-4
-
Homo sapiens
3.4.14.5 DPP-4
-
Rattus norvegicus
3.4.14.5 DPP-4
-
Sus scrofa