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Literature summary extracted from

  • Gaboriau, D.; Howes, E.A.; Clark, J.; Jones, R.
    Binding of sperm proacrosin/beta-acrosin to zona pellucida glycoproteins is sulfate and stereodependent. Synthesis of a novel fertilization inhibitor (2007), Dev. Biol., 306, 646-657.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.10 additional information no inhibition with quercetin-3beta-D-glucoside or quercetin-3beta-D-glucoside sulfate Sus scrofa
3.4.21.10 NF064
-
Sus scrofa
3.4.21.10 NSC651015
-
Sus scrofa
3.4.21.10 NSC651016
-
Sus scrofa
3.4.21.10 suramin
-
Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.10 additional information Sus scrofa proacrosin involved in stereospecific sulfate binding that mediates the retention of post-acrosome reaction spermatozoa on the zona pellucida surface ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.10 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.10
-
Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.10 spermatozoon
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.10 additional information proacrosin involved in stereospecific sulfate binding that mediates the retention of post-acrosome reaction spermatozoa on the zona pellucida surface Sus scrofa ?
-
?
3.4.21.10 Nalpha-benzoyl-L-arginine 4-nitroanilide hydrochloride + H2O
-
Sus scrofa ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.10 beta-acrosin residues 1-322, activated form of proacrosin (residues 1-399) Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.10 0.012
-
23°C Sus scrofa NF064
3.4.21.10 0.1
-
23°C Sus scrofa suramin
3.4.21.10 0.7
-
23°C Sus scrofa NSC651015
3.4.21.10 0.7
-
23°C Sus scrofa NSC651016