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Literature summary extracted from

  • Ueki, M.; Takeshita, H.; Fujihara, J.; Ueta, G.; Nakajima, T.; Kominato, Y.; Kishi, K.; Iida, R.; Yasuda, T.
    Susceptibility of mammalian deoxyribonucleases I (DNases I) to proteolysis by proteases and its relationships to tissue distribution: Biochemical and molecular analysis of equine DNase I (2007), Comp. Biochem. Physiol. B, 148B, 93-102.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.21.1 expression in COS-7 cell Equus caballus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.21.1 EDTA 10 mM, complete loss of activity Equus caballus
3.1.21.1 EGTA 1 mM, complete loss of activity Equus caballus

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.1 Equus caballus Q4AEE3
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.21.1 glycoprotein protein contains a N-linked carbohydrate moiety. Potential glycosylation sites at N18 and N106 Equus caballus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.21.1 from parotid gland Equus caballus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.21.1 kidney poor activity Equus caballus
-
3.1.21.1 liver poor activity Equus caballus
-
3.1.21.1 additional information marked correlation between tissue distribution of enzyme and its sensitivity/resistance to proteolysis Equus caballus
-
3.1.21.1 pancreas poor activity Equus caballus
-
3.1.21.1 parotid gland high activity Equus caballus
-
3.1.21.1 small intestine poor activity Equus caballus
-
3.1.21.1 submaxillary gland poor activity Equus caballus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.21.1 3600
-
 pH 6.5 Equus caballus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.21.1 DNA + H2O
-
 Equus caballus 5'-phosphodinucleotide + 5'-phosphooligonucleotide
-
 ?