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Literature summary extracted from
- Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate (2007), Chem. Res. Toxicol., 20, 975-981.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.6.2.2 | C455A | mutant is 1.5fold more sensitive to 1,4-benzoquinone and 2-(4-chlorophenyl)benzo-1,4-quinone, but shows wild-type sensitivity to traditional topoisomerase II poisons | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.2.2 | 1,4-benzoquinone | inhibition by blocking the N-terminal gate of enzyme | Homo sapiens |  |
| 5.6.2.2 | 2-(4-chlorophenyl)benzo-1,4-quinone | inhibition by blocking the N-terminal gate of enzyme | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.2.2 | Homo sapiens | - |
isoform topoisomerase IIalpha | - |
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Release 2023.1 (January 2023)
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