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Literature summary extracted from

  • Jafari, C.; Panzer, U.; Steinmetz, O.M.; Zahner, G.; Stahl, R.A.; Harendza, S.
    Enhanced expression of selenocysteine lyase in acute glomerulonephritis and its regulation by AP-1 (2006), Cell. Mol. Biol. Lett., 11, 424-437.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.4.1.16 medicine expression of selenocysteine lyase is higher in acute and lower in chronic glomerulonephritis, selenocysteine lyase is upregulated by IL1b in acute nephritis leading to the synthesis of selenoproteins, which act as oxygen radical scavengers and lead to the limitation and resolution of acute glomerular inflammation Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.16 expression in Escherichia coli into the pGEM-T Easy vector for sequencing, 5’ constructs with deletions in the promoter region are subcloned into the promoterless luciferase expression vector Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.16 Rattus norvegicus
-
 Sprague-Dawley
-
4.4.1.16 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.16 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.16 D-cysteine + H2O
-
 Rattus norvegicus sulfide + NH3 + pyruvate
-
 ?
4.4.1.16 D-cysteine + H2O
-
 Rattus norvegicus Sprague-Dawley sulfide + NH3 + pyruvate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.16 L-selenocysteine selenide-lyase
-
 Rattus norvegicus
4.4.1.16 SCL
-
 Rattus norvegicus
4.4.1.16 selenocysteine lyase
-
 Rattus norvegicus