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Literature summary extracted from

  • Antognelli, C.; Baldracchini, F.; Talesa, V.N.; Costantini, E.; Zucchi, A.; Mearini, E.
    Overexpression of glyoxalase system enzymes in human kidney tumor (2006), Cancer J., 12, 222-228.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.4.1.5 medicine possible role of glyoxalase I in the chemoresistance displayed by kidney tumor, possible use of glyoxalase I inhibitors as anticancer drugs, increase in glyoxalase I lowers level of the potent apoptosis activator methylglyoxal Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.6 Homo sapiens
-
-
-
4.4.1.5 Homo sapiens
-
-
-
4.4.1.5 Homo sapiens Q04760
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.6 kidney
-
 Homo sapiens
-
3.1.2.6 kidney tumor cell transcription of glyoxalase II is about threefold increased in cancerous tissue comared to noncancerous tissue. Glyoxalase II activity is significantly lower in pathological tissues than in normal ones Homo sapiens
-
4.4.1.5 kidney
-
 Homo sapiens
-
4.4.1.5 kidney tumor cell transcription level and glyoxalase I activity are higher in pathological tissues than in normal ones Homo sapiens
-
4.4.1.5 additional information renal carcinoma cell, clear cell adenocarcinoma, 9fold increase in the transcription levels of glyoxalase I compared with pair-matched noncancerous tissues Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.6 S-D-lactoylglutathione + H2O
-
 Homo sapiens D-lactate + glutathione
-
 ?
4.4.1.5 glutathione + methylglyoxal
-
 Homo sapiens S-lactoylglutathione
-
 ?
4.4.1.5 glutathione + methylglyoxal
-
 Homo sapiens S-D-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.6 glyoxalase II
-
 Homo sapiens
4.4.1.5 glyoxalase I
-
 Homo sapiens