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Literature summary extracted from

  • Werkstroem, V.; Svensson, A.; Andersson, K.E.; Hedlund, P.
    Phosphodiesterase 5 in the female pig and human urethra: morphological and functional aspects (2006), BJU Int., 98, 414-423.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.35 sildenafil nerve-induced relaxation of urethral preparations are enhanced at low concentrations of sildenafil, with direct smooth muscle-relaxant actions of the inhibitors at high concentrations Sus scrofa
3.1.4.35 tadalafil nerve-induced relaxation of urethral preparations are enhanced at low concentrations of tadalafil, with direct smooth muscle-relaxant actions of the inhibitors at high concentrations Sus scrofa
3.1.4.35 vardenafil nerve-induced relaxation of urethral preparations are enhanced at low concentrations of vardenafil, with direct smooth muscle-relaxant actions of the inhibitors at high concentrations Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.35 Sus scrofa
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.35 urethra wide distribution of enzyme isoform PDE5, nerve-induced relaxation of urethral preparations are enhanced at low concentrations of enzyme inhibitors sildenafil, vardenafil, and tadalafil, with direct smooth muscle-relaxant actions of the inhibitors at high concentrations Sus scrofa
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