Literature summary extracted from

Ohshita, T.; Hiroi, Y.
Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase (2006), Biosci. Biotechnol. Biochem., 70, 2254-2261.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.22.15	(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucine(3-methylbutyl)-amide	0.01 mg/ml	Rattus norvegicus
3.4.22.15	cystatin alpha	0.05 mg/ml	Rattus norvegicus
3.4.22.15	leupeptin	0.1 mg/ml	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.22.15	lysosome	-	Rattus norvegicus	5764	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.4.22.15	24000	-	SDS-PAGE	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.15	Rattus norvegicus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.4.22.15	Sephacryl S200 gel filtration and CM-Sephadex gel filtration	Rattus norvegicus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.15	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.22.15	benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O	-	Rattus norvegicus	benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?
3.4.22.15	L-lactate dehydrogenase + H2O	-	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)