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Literature summary extracted from

  • Miyazawa, Y.; Nishioka, H.; Yura, K.; Yamato, T.
    Discrimination of class I CPD photolyase from blue light photoreceptors by single methionine residue (2008), Biophys. J., 94, 2194-2203.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.1.99.3 additional information by evolutionary sequence analysis it is shown that Met353 of the CPD photolyase derived from Anacystis nidulans is perfectly conserved throughout the putative class I CPD photolyase Synechococcus elongatus PCC 7942 = FACHB-805
4.1.99.3 additional information Met-353 of the CPD photolyase has been perfectly conserved throughout the putative class I CPD photolyases and plays a pivotal role in the biological function of DNA photolyase Synechococcus elongatus PCC 7942 = FACHB-805

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.3 Synechococcus elongatus PCC 7942 = FACHB-805
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.99.3 cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) by molecular dynamics simulation and quantum mechanical calculations it is shown that indirect electron tunneling via the protein medium is as important as direct electron transfer from the donor (FADH-) to the acceptor (cyclobutane pyrimidine dimmer). At Met353 site busy electron tunneling traffic is observed. Synechococcus elongatus PCC 7942 = FACHB-805
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.3 cyclobutadipyrimidine in DNA DNA photolyase recognizes ultraviolet-damaged DNA and breaks improperly formed covalent bonds within the cyclobutane pyrimidine dimer by a light-activated electron transfer reaction between FAD and cyclobutane pyrimidine dimer Synechococcus elongatus PCC 7942 = FACHB-805 pyrimidine residues in DNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.99.3 class I CPD photolyase
-
 Synechococcus elongatus PCC 7942 = FACHB-805
4.1.99.3 class I cyclobutane pyrimidine dimer photolyase
-
 Synechococcus elongatus PCC 7942 = FACHB-805
4.1.99.3 CPD photolyase
-
 Synechococcus elongatus PCC 7942 = FACHB-805
4.1.99.3 DNA photolyase
-
 Synechococcus elongatus PCC 7942 = FACHB-805

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.99.3 FAD
-
 Synechococcus elongatus PCC 7942 = FACHB-805
4.1.99.3 FADH2
-
 Synechococcus elongatus PCC 7942 = FACHB-805