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Literature summary extracted from
- Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin (2008), Bioorg. Med. Chem. Lett., 18, 479-484.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.14.5 | atorvastatin | competitive | Sus scrofa |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.14.5 | glucagon-like peptide-1 + H2O | Sus scrofa | dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide | ? | - |
? | |
| 3.4.14.5 | glucose-dependent insulinotropic polypeptide + H2O | Sus scrofa | dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.14.5 | Sus scrofa | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.14.5 | glucagon-like peptide-1 + H2O | dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide | Sus scrofa | ? | - |
? | |
| 3.4.14.5 | glucose-dependent insulinotropic polypeptide + H2O | dipeptidyl peptidase-IV is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1and glucose-dependent insulinotropic polypeptide | Sus scrofa | ? | - |
? | |
| 3.4.14.5 | Gly-Pro-p-nitroanilide + H2O | - |
Sus scrofa | Gly-Pro + p-nitroaniline | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.14.5 | dipeptidyl peptidase-IV | - |
Sus scrofa |
| 3.4.14.5 | DPP-IV | - |
Sus scrofa |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.14.5 | 0.0578 | - |
atorvastatin | 37°C, pH 8.0 | Sus scrofa | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.14.5 | 0.175 | - |
37°C, pH 8.0 | Sus scrofa | atorvastatin | |
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Release 2023.1 (January 2023)
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