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Literature summary extracted from

  • More, S.S.; Vince, R.
    Design, synthesis, and binding studies of bidentate Zn-chelating peptidic inhibitors of glyoxalase-I (2007), Bioorg. Med. Chem. Lett., 17, 3793-3797.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.4.1.5 drug development beta-ketoesters function as a possible zinc-chelating component of Glx-I inhibitors Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.5 L-gamma-glutamyl-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine tight-binding carboanalog of hydroxamate Saccharomyces cerevisiae
4.4.1.5 N-[(1S,4Z)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohept-4-en-1-yl]-L-glutamine beta-ketoester, competetive inhibitor Saccharomyces cerevisiae
4.4.1.5 N-[(1S,4Z)-6-(4-bromophenyl)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohex-4-en-1-yl]-L-glutamine beta-ketoester, competetive inhibitor Saccharomyces cerevisiae
4.4.1.5 N2-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine tight-binding carboanalog of hydroxamate Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.5 0.5
-
 methylglyoxal
-
 Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.4.1.5 Zn2+
-
 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 glutathione + methylglyoxal
-
 Saccharomyces cerevisiae S-D-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 glyoxalase-I
-
 Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.4.1.5 0.00000617
-
 L-gamma-glutamyl-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine
-
 Saccharomyces cerevisiae
4.4.1.5 0.0000326
-
 N2-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine
-
 Saccharomyces cerevisiae
4.4.1.5 0.06688
-
 N-[(1S,4Z)-6-(4-bromophenyl)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohex-4-en-1-yl]-L-glutamine
-
 Saccharomyces cerevisiae
4.4.1.5 0.1124
-
 N-[(1S,4Z)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohept-4-en-1-yl]-L-glutamine
-
 Saccharomyces cerevisiae