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Literature summary extracted from
- A metabolically stable tight-binding transition-state inhibitor of glyoxalase-I (2006), Bioorg. Med. Chem. Lett., 16, 6039-6042.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.4.1.5 | drug development | design of a metabolically stable glyoxalase-I inhibitor, which may be useful in potentiating the antitumor activity of alpha-ketoaldehydes | Saccharomyces cerevisiae |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.5 | L-gamma-glutamyl-S-[(4-bromophenyl)(hydroxy)carbamoyl]-L-cysteinylglycine | hydroxamic acid-based transition state inhibitor, unstable toward gamma-glutamyltranspeptidase | Saccharomyces cerevisiae |  |
| 4.4.1.5 | N-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-S-[(4-bromophenyl)(hydroxy)carbamoyl]-L-cysteinylglycine | tight-binding competitive inhibitor, stable toward gamma-glutamyltranspeptidase | Saccharomyces cerevisiae | |
| 4.4.1.5 | S-p-bromobenzyl glutathione | competitive inhibitor, unstable toward gamma-glutamyltranspeptidase | Saccharomyces cerevisiae | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.5 | 0.35 | - |
glutathione | - |
Saccharomyces cerevisiae | |
| 4.4.1.5 | 0.35 | - |
methylglyoxal | - |
Saccharomyces cerevisiae | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.5 | Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.5 | glutathione + methylglyoxal | - |
Saccharomyces cerevisiae | S-D-lactoylglutathione | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.4.1.5 | Glx-I | - |
Saccharomyces cerevisiae |
| 4.4.1.5 | glyoxalase-I | - |
Saccharomyces cerevisiae |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.4.1.5 | 6.6 | - |
- |
Saccharomyces cerevisiae |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.5 | 0.00219 | - |
N-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-S-[(4-bromophenyl)(hydroxy)carbamoyl]-L-cysteinylglycine | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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