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Literature summary extracted from

  • Hoshino, T.; Tamegai, H.; Kakinuma, K.; Eguchi, T.
    Inhibition of type 2 isopentenyl diphosphate isomerase from Methanocaldococcus jannaschii by a mechanism-based inhibitor of type 1 isopentenyl diphosphate isomerase (2006), Bioorg. Med. Chem., 14, 6555-6559.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.3.2 3,4-epoxy-3-methylbutyl diphosphate i.e. EIPP, mechanism-based inhibitor of type I enzyme, covalent modification of reduced FMN in N5 position Methanocaldococcus jannaschii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.3.2 15.3
-
isopentenyl diphosphate pH 7.0, 85°C Methanocaldococcus jannaschii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.3.2 39897
-
x * 39897, mass spectrometry Methanocaldococcus jannaschii

Organism

EC Number Organism UniProt Comment Textmining
5.3.3.2 Methanocaldococcus jannaschii
-
type II enzyme, isoform IDI-2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.3.2 isopentenyl diphosphate
-
Methanocaldococcus jannaschii dimethylallyl diphosphate
-
?

Subunits

EC Number Subunits Comment Organism
5.3.3.2 ? x * 39897, mass spectrometry Methanocaldococcus jannaschii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.3.3.2 85 95
-
Methanocaldococcus jannaschii

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.3.3.2 191
-
isopentenyl diphosphate pH 7.0, 85°C Methanocaldococcus jannaschii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3.3.2 7 7.2
-
Methanocaldococcus jannaschii

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.3.3.2 0.0565
-
3,4-epoxy-3-methylbutyl diphosphate pH 7.0, 85°C Methanocaldococcus jannaschii