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Literature summary extracted from

  • Lindner, H.A.; Taefler-Naumann, M.; Roehm, K.H.
    N-acetylamino acid utilization by kidney aminoacylase-1 (2008), Biochimie, 90, 773-780.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.14 expression in Baculovirus Sus scrofa
3.5.1.14 expression in Baculovirus Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.14 DTT
-
 Homo sapiens
3.5.1.14 DTT
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.14 0.43
-
 N-acetyl-L-methionine 25°C, pH7.4 Homo sapiens
3.5.1.14 0.44
-
 N-acetyl-L-norleucine 25°C, pH7.4 Homo sapiens
3.5.1.14 1.28
-
 N-acetyl-L-ethionine 25°C, pH7.4 Homo sapiens
3.5.1.14 1.4
-
 N-acetyl-L-cysteine 25°C, pH7.4 Homo sapiens
3.5.1.14 1.5
-
 N-acetyl-L-cysteine 25°C, pH 7.4 Sus scrofa
3.5.1.14 1.57
-
 N-acetyl-L-norleucine 25°C, pH 7.4 Sus scrofa
3.5.1.14 1.87
-
 N-acetyl-L-ethionine 25°C, pH 7.4 Sus scrofa
3.5.1.14 2.4
-
 N-acetyl-L-leucine 25°C, pH7.4 Homo sapiens
3.5.1.14 2.72
-
 N-acetyl-L-methionine 25°C, pH 7.4 Sus scrofa
3.5.1.14 3.8
-
 N-acetyl-L-leucine 25°C, pH 7.4 Sus scrofa
3.5.1.14 4.81
-
 N-acetyl-L-phenylalanine 25°C, pH7.4 Homo sapiens
3.5.1.14 6.72
-
 N-acetyl-L-isoleucine 25°C, pH 7.4 Sus scrofa
3.5.1.14 10.3
-
 N-acetyl-L-phenylalanine 25°C, pH 7.4 Sus scrofa
3.5.1.14 11.4
-
 N-acetyl-L-valine 25°C, pH7.4 Homo sapiens
3.5.1.14 11.9
-
 N-acetyl-L-histidine 25°C, pH 7.4 Sus scrofa
3.5.1.14 16.6
-
 N-acetyl-L-valine 25°C, pH 7.4 Sus scrofa
3.5.1.14 20.1
-
 N-acetyl-L-alanine 25°C, pH7.4 Homo sapiens
3.5.1.14 22.7
-
 N-acetyl-L-histidine 25°C, pH7.4 Homo sapiens
3.5.1.14 27.7
-
 N-acetyl-L-asparagine 25°C, pH7.4 Homo sapiens
3.5.1.14 30.9
-
 N-acetyl-L-threonine 25°C, pH 7.4 Sus scrofa
3.5.1.14 32.5
-
 N-acetyl-L-threonine 25°C, pH7.4 Homo sapiens
3.5.1.14 34.8
-
 N-acetyl-L-arginine 25°C, pH 7.4 Sus scrofa
3.5.1.14 43.6
-
 N-acetyl-glycine 25°C, pH 7.4 Sus scrofa
3.5.1.14 57.6
-
 N-acetyl-L-glutamine 25°C, pH 7.4 Sus scrofa
3.5.1.14 59.9
-
 N-acetyl-glycine 25°C, pH7.4 Homo sapiens
3.5.1.14 62.3
-
 N-acetyl-L-glutamine 25°C, pH7.4 Homo sapiens
3.5.1.14 63
-
 N-acetyl-L-glutamate 25°C, pH7.4 Homo sapiens
3.5.1.14 102
-
 N-acetyl-L-glutamate 25°C, pH 7.4 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.14 cytoplasm
-
 Sus scrofa 5737
-
3.5.1.14 cytoplasm
-
 Homo sapiens 5737
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.14 Homo sapiens Q03154
-
-
3.5.1.14 Sus scrofa P37111
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.14 kidney
-
 Sus scrofa
-
3.5.1.14 kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.14 N-acetyl-glycine + H2O
-
 Sus scrofa acetate + glycine
-
 ?
3.5.1.14 N-acetyl-glycine + H2O
-
 Homo sapiens acetate + glycine
-
 ?
3.5.1.14 N-acetyl-L-alanine + H2O
-
 Homo sapiens acetate + L-alanine
-
 ?
3.5.1.14 N-acetyl-L-arginine + H2O
-
 Sus scrofa acetate + L-arginine
-
 ?
3.5.1.14 N-acetyl-L-asparagine + H2O
-
 Homo sapiens acetate + L-asparagine
-
 ?
3.5.1.14 N-acetyl-L-cysteine + H2O
-
 Sus scrofa acetate + L-cysteine
-
 ?
3.5.1.14 N-acetyl-L-cysteine + H2O
-
 Homo sapiens acetate + L-cysteine
-
 ?
3.5.1.14 N-acetyl-L-ethionine + H2O
-
 Sus scrofa acetate + L-ethionine
-
 ?
3.5.1.14 N-acetyl-L-ethionine + H2O
-
 Homo sapiens acetate + L-ethionine
-
 ?
3.5.1.14 N-acetyl-L-glutamate + H2O
-
 Sus scrofa acetate + L-glutamate
-
 ?
3.5.1.14 N-acetyl-L-glutamate + H2O
-
 Homo sapiens acetate + L-glutamate
-
 ?
3.5.1.14 N-acetyl-L-glutamine + H2O
-
 Sus scrofa acetate + L-glutamine
-
 ?
3.5.1.14 N-acetyl-L-glutamine + H2O
-
 Homo sapiens acetate + L-glutamine
-
 ?
3.5.1.14 N-acetyl-L-histidine + H2O
-
 Sus scrofa acetate + L-histidine
-
 ?
3.5.1.14 N-acetyl-L-histidine + H2O
-
 Homo sapiens acetate + L-histidine
-
 ?
3.5.1.14 N-acetyl-L-isoleucine + H2O
-
 Sus scrofa acetate + L-isoleucine
-
 ?
3.5.1.14 N-acetyl-L-leucine + H2O
-
 Sus scrofa acetate + L-leucine
-
 ?
3.5.1.14 N-acetyl-L-leucine + H2O
-
 Homo sapiens acetate + L-leucine
-
 ?
3.5.1.14 N-acetyl-L-methionine + H2O
-
 Sus scrofa acetate + L-methionine
-
 ?
3.5.1.14 N-acetyl-L-methionine + H2O
-
 Homo sapiens acetate + L-methionine
-
 ?
3.5.1.14 N-acetyl-L-norleucine + H2O
-
 Sus scrofa acetate + L-norleucine
-
 ?
3.5.1.14 N-acetyl-L-norleucine + H2O
-
 Homo sapiens acetate + L-norleucine
-
 ?
3.5.1.14 N-acetyl-L-phenylalanine + H2O
-
 Sus scrofa acetate + L-phenylalanine
-
 ?
3.5.1.14 N-acetyl-L-phenylalanine + H2O
-
 Homo sapiens acetate + L-phenylalanine
-
 ?
3.5.1.14 N-acetyl-L-threonine + H2O
-
 Sus scrofa acetate + L-threonine
-
 ?
3.5.1.14 N-acetyl-L-threonine + H2O
-
 Homo sapiens acetate + L-threonine
-
 ?
3.5.1.14 N-acetyl-L-valine + H2O
-
 Sus scrofa acetate + L-valine
-
 ?
3.5.1.14 N-acetyl-L-valine + H2O
-
 Homo sapiens acetate + L-valine
-
 ?
3.5.1.14 N-acyl-L-amino acid + H2O
-
 Homo sapiens carboxylate + L-amino acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.14 hAcy1
-
 Homo sapiens
3.5.1.14 pAcy1
-
 Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.1.14 0.04 1.97 N-acetyl-L-arginine 25°C, pH 7.4 Sus scrofa
3.5.1.14 0.14
-
 N-acetyl-L-phenylalanine 25°C, pH7.4 Homo sapiens
3.5.1.14 0.81
-
 N-acetyl-L-phenylalanine 25°C, pH 7.4 Sus scrofa
3.5.1.14 1.2
-
 N-acetyl-L-histidine 25°C, pH7.4 Homo sapiens
3.5.1.14 1.21
-
 N-acetyl-L-threonine 25°C, pH 7.4 Sus scrofa
3.5.1.14 1.28
-
 N-acetyl-L-isoleucine 25°C, pH 7.4 Sus scrofa
3.5.1.14 2.23
-
 N-acetyl-L-threonine 25°C, pH7.4 Homo sapiens
3.5.1.14 2.77
-
 N-acetyl-L-histidine 25°C, pH 7.4 Sus scrofa
3.5.1.14 7.6
-
 N-acetyl-glycine 25°C, pH 7.4 Sus scrofa
3.5.1.14 8.53
-
 N-acetyl-L-arginine 25°C, pH 7.4 Sus scrofa
3.5.1.14 11.9
-
 N-acetyl-L-valine 25°C, pH 7.4 Sus scrofa
3.5.1.14 12.4
-
 N-acetyl-L-ethionine 25°C, pH7.4 Homo sapiens
3.5.1.14 14.7
-
 N-acetyl-L-valine 25°C, pH7.4 Homo sapiens
3.5.1.14 28.1
-
 N-acetyl-L-cysteine 25°C, pH7.4 Homo sapiens
3.5.1.14 30.7
-
 N-acetyl-L-glutamine 25°C, pH7.4 Homo sapiens
3.5.1.14 31.7
-
 N-acetyl-glycine 25°C, pH7.4 Homo sapiens
3.5.1.14 34.7
-
 N-acetyl-L-cysteine 25°C, pH 7.4 Sus scrofa
3.5.1.14 38.3
-
 N-acetyl-L-methionine 25°C, pH7.4 Homo sapiens
3.5.1.14 55.5
-
 N-acetyl-L-leucine 25°C, pH7.4 Homo sapiens
3.5.1.14 68.3
-
 N-acetyl-L-ethionine 25°C, pH 7.4 Sus scrofa
3.5.1.14 134
-
 N-acetyl-L-methionine 25°C, pH 7.4 Sus scrofa
3.5.1.14 146
-
 N-acetyl-L-glutamine 25°C, pH 7.4 Sus scrofa
3.5.1.14 156
-
 N-acetyl-L-glutamate 25°C, pH7.4 Homo sapiens
3.5.1.14 156
-
 N-acetyl-L-norleucine 25°C, pH7.4 Homo sapiens
3.5.1.14 160
-
 N-acetyl-L-leucine 25°C, pH 7.4 Sus scrofa
3.5.1.14 207
-
 N-acetyl-L-glutamate 25°C, pH 7.4 Sus scrofa
3.5.1.14 266
-
 N-acetyl-L-norleucine 25°C, pH 7.4 Sus scrofa