BRENDA - Enzyme Database

Phospholipid and fatty acid specificity of endothelial lipase: Potential role of the enzyme in the delivery of docosahexaenoic acid (DHA) to tissues

Chen, S.; Subbaiah, P.V.; Biochim. Biophys. Acta 1771, 1319-1328 (2007)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.1.32
extracellular
the enzyme is secreted by the cells of the blood-brain barrier
Homo sapiens
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.1.32
additional information
Homo sapiens
the enzyme plays an important role in the metabolism of high density lipoproteins, it may be responsible for the generation of docosahexaenoic acid DHA lysophospholipids in plasma, DHA is important in brain development and neurological function, the endothelial lipase is important in the delivery of DHA lysophospholipid carriers to the brain, overview
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.1.32
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.32
brain
the enzyme is secreted by the cells of the blood-brain barrier
Homo sapiens
-
3.1.1.32
plasma
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.32
additional information
substrate specificity, overview
678433
Homo sapiens
?
-
-
-
-
3.1.1.32
additional information
the enzyme plays an important role in the metabolism of high density lipoproteins, it may be responsible for the generation of docosahexaenoic acid DHA lysophospholipids in plasma, DHA is important in brain development and neurological function, the endothelial lipase is important in the delivery of DHA lysophospholipid carriers to the brain, overview
678433
Homo sapiens
?
-
-
-
-
3.1.1.32
phosphatidylcholine + H2O
phosphatidylcholine from shark liver
678433
Homo sapiens
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
3.1.1.32
phosphatidylethanolamine + H2O
docosahexaenoic acid-enriched phosphatidylethanolamine vesicles
678433
Homo sapiens
?
-
-
-
?
3.1.1.32
phosphatidylserine + H2O
docosahexaenoic acid-enriched phosphatidylserine vesicles
678433
Homo sapiens
?
-
-
-
?
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.1.32
extracellular
the enzyme is secreted by the cells of the blood-brain barrier
Homo sapiens
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.1.32
additional information
Homo sapiens
the enzyme plays an important role in the metabolism of high density lipoproteins, it may be responsible for the generation of docosahexaenoic acid DHA lysophospholipids in plasma, DHA is important in brain development and neurological function, the endothelial lipase is important in the delivery of DHA lysophospholipid carriers to the brain, overview
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.32
brain
the enzyme is secreted by the cells of the blood-brain barrier
Homo sapiens
-
3.1.1.32
plasma
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.32
additional information
substrate specificity, overview
678433
Homo sapiens
?
-
-
-
-
3.1.1.32
additional information
the enzyme plays an important role in the metabolism of high density lipoproteins, it may be responsible for the generation of docosahexaenoic acid DHA lysophospholipids in plasma, DHA is important in brain development and neurological function, the endothelial lipase is important in the delivery of DHA lysophospholipid carriers to the brain, overview
678433
Homo sapiens
?
-
-
-
-
3.1.1.32
phosphatidylcholine + H2O
phosphatidylcholine from shark liver
678433
Homo sapiens
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
3.1.1.32
phosphatidylethanolamine + H2O
docosahexaenoic acid-enriched phosphatidylethanolamine vesicles
678433
Homo sapiens
?
-
-
-
?
3.1.1.32
phosphatidylserine + H2O
docosahexaenoic acid-enriched phosphatidylserine vesicles
678433
Homo sapiens
?
-
-
-
?