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Literature summary extracted from

  • Craig, D.H.; Moody, P.C.; Bruce, N.C.; Scrutton, N.S.
    Reductive and oxidative half-reactions of morphinone reductase from Pseudomonas putida M10: a kinetic and thermodynamic analysis (1998), Biochemistry, 37, 7598-7607.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.42 expressed in Escherichia coli Pseudomonas putida

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.42 cortisone
-
 Pseudomonas putida
1.3.1.42 progesterone
-
 Pseudomonas putida

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.42 41100
-
 2 * 41100 Pseudomonas putida
1.3.1.42 82200
-
-
 Pseudomonas putida

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.42 Pseudomonas putida
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.42 2-cyclohexen-1-one + NADH
-
 Pseudomonas putida ? + NAD+
-
 ?
1.3.1.42 codeinone + NADH
-
 Pseudomonas putida hydrocodone + NAD+
-
 ?
1.3.1.42 morphinone + NADH
-
 Pseudomonas putida hydromorphone + NAD+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.1.42 homodimer 2 * 41100 Pseudomonas putida

Synonyms

EC Number Synonyms Comment Organism
1.3.1.42 morphine reductase the enzyme is closely related to the isoforms of old yellow enzyme with major differences in the kinetic properties Pseudomonas putida

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.42 flavin dependent, contains one molar equivalent of noncovalently bound FMN per enzyme subunit Pseudomonas putida
1.3.1.42 NADH dependent Pseudomonas putida