BRENDA - Enzyme Database show

Dihydrodipicolinate synthase from Thermotoga maritima

Pearce, F.G.; Perugini, M.A.; McKerchar, H.J.; Gerrard, J.A.; Biochem. J. 400, 359-366 (2006)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
4.3.3.7
-
Thermotoga maritima
Crystallization (Commentary)
EC Number
Crystallization
Organism
4.3.3.7
the X-ray crystal structure is described
Thermotoga maritima
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.3.3.7
additional information
not inhibited by (S)-lysine, suggesting that feedback control of the lysine biosynthetic pathway evolves later in the bacterial lineage
Thermotoga maritima
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.3.3.7
33800
-
4 * 33800, calculated from sequence
Thermotoga maritima
4.3.3.7
133000
-
sedimentation equilibrium analysis
Thermotoga maritima
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.3.3.7
(S)-aspartate 4-semialdehyde + pyruvate
Thermotoga maritima
catalyses the branch point in lysine biosynthesis
dihydrodipicolinate + H2O
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.3.3.7
Thermotoga maritima
Q9X1K9
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.3.3.7
-
Thermotoga maritima
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.3.3.7
(S)-aspartate 4-semialdehyde + pyruvate
catalyses the branch point in lysine biosynthesis
678046
Thermotoga maritima
dihydrodipicolinate + H2O
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
4.3.3.7
tetramer
4 * 33800, calculated from sequence
Thermotoga maritima
Temperature Stability [°C]
EC Number
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
4.3.3.7
90
-
7 h, 40% loss of activity. When the enzyme is incubated at 90°C in 8M urea, 60% of the activity is lost after 90 min
Thermotoga maritima
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
4.3.3.7
-
Thermotoga maritima
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
4.3.3.7
the X-ray crystal structure is described
Thermotoga maritima
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.3.3.7
additional information
not inhibited by (S)-lysine, suggesting that feedback control of the lysine biosynthetic pathway evolves later in the bacterial lineage
Thermotoga maritima
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.3.3.7
33800
-
4 * 33800, calculated from sequence
Thermotoga maritima
4.3.3.7
133000
-
sedimentation equilibrium analysis
Thermotoga maritima
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.3.3.7
(S)-aspartate 4-semialdehyde + pyruvate
Thermotoga maritima
catalyses the branch point in lysine biosynthesis
dihydrodipicolinate + H2O
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.3.3.7
-
Thermotoga maritima
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.3.3.7
(S)-aspartate 4-semialdehyde + pyruvate
catalyses the branch point in lysine biosynthesis
678046
Thermotoga maritima
dihydrodipicolinate + H2O
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
4.3.3.7
tetramer
4 * 33800, calculated from sequence
Thermotoga maritima
Temperature Stability [°C] (protein specific)
EC Number
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
4.3.3.7
90
-
7 h, 40% loss of activity. When the enzyme is incubated at 90°C in 8M urea, 60% of the activity is lost after 90 min
Thermotoga maritima