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Literature summary extracted from

  • Li, W.; Chen, H.Y.; Davie, J.R.
    Properties of chicken erythrocyte histone deacetylase associated with the nuclear matrix (1996), Biochem. J., 314, 631-637.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.98 additional information in Tris/HCl buffer, optimum concentration of NaCl is 50 mM for isoforms HD1 and HD2 and 100 mM for the nuclear matrix form Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 Butyrate non-competitive Gallus gallus
3.5.1.98 additional information in phosphate buffer, the presence of NaCl is inhibitory Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.98 nuclear matrix associated to Gallus gallus 16363
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.98 55000
-
 isoform HD1, gel filtration Gallus gallus
3.5.1.98 220000
-
 isoform HD2, gel filtration Gallus gallus
3.5.1.98 400000
-
 enzyme complex solubilized from nuclear matrix, gel filtration Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Gallus gallus
-
 isoforms HD1 and HD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 erythrocyte
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.98 N6-lysine acetylated histone H2A-H2B dimer + H2O isoform HD2, slightly preferred substrate Gallus gallus histone H3-H4 dimer + acetate
-
 ?
3.5.1.98 N6-lysine acetylated histone H3-H4 tetramer + H2O isoform HD1, preferred substrate Gallus gallus histone H3-H4 tetramer + acetate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.1.98 More isoform HD2 dissociates into HD1 when treated with 1.6 M NaCl or applied to a Q-Sepharose column. The active form of enzyme is a high-molecular-mass complex associated with proteins that are components of the nuclear matrix Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.98 6.5 7 isoform HD2 Gallus gallus
3.5.1.98 7 7.5 nuclear matrix form of enzyme Gallus gallus
3.5.1.98 7.5
-
 isoform HD1 Gallus gallus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.98 0.021
-
 isoform HD2 Gallus gallus Butyrate
3.5.1.98 0.045
-
 isoform HD1 Gallus gallus Butyrate
3.5.1.98 0.08
-
 nuclear matrix form of enzyme Gallus gallus Butyrate