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Literature summary extracted from
- Purification and characterization of acetylcholinesterase from sheep liver and inhibition by some painkillers (2006), Asian J. Chem., 18, 1097-1103.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | neostigmine methylsulfate | painkiller | Ovis aries |  |
| 3.1.1.7 | paracetamol/caffeine | painkiller preparation | Ovis aries | |
| 3.1.1.7 | paracetamol/propifenazone/caffeine | painkiller preparation | Ovis aries | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.7 | ammonium sulfate | activates optimally at 0.2 M | Ovis aries | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | Ovis aries | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.7 | native enzyme from liver 3541.7fold to homogeneity by affinity chromatography | Ovis aries |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.7 | liver | - |
Ovis aries | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.7 | acetylthiocholine + H2O | - |
Ovis aries | thiocholine + acetate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.7 | AChE | - |
Ovis aries |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 35 | - |
- |
Ovis aries |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.7 | 7.5 | 8.5 | - |
Ovis aries |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.7 | 1.02 | - |
neostigmine methylsulfate | - |
Ovis aries | |
| 3.1.1.7 | 1.24 | - |
paracetamol/propifenazone/caffeine | - |
Ovis aries | |
| 3.1.1.7 | 1.27 | - |
paracetamol/caffeine | - |
Ovis aries | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.7 | 1.246 | - |
- |
Ovis aries | paracetamol/caffeine | |
| 3.1.1.7 | 1.646 | - |
- |
Ovis aries | paracetamol/propifenazone/caffeine | |
| 3.1.1.7 | 4.326 | - |
- |
Ovis aries | neostigmine methylsulfate | |
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Release 2023.1 (January 2023)
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