Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yoon, H.J.; Park, S.W.; Lee, H.B.; Im, S.Y.; Hooper, N.M.; Park, H.S.
    Release of renal dipeptidase from glycosylphosphatidylinositol anchor by insulin-triggered phospholipase C/intracellular Ca2+ (2007), Arch. Pharm. Res., 30, 608-615.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.11 Insulin in part, may activate GPI-PLC, via phosphatidylinositol-specific phospholipase C/intracellular Ca2+, which may consequently stimulate the release of GPI-renal dipeptidase Sus scrofa
3.4.13.19 Insulin stimulates indirectly the release of RDPase in association with Ca2+ in a concentration-dependent manner (half maximal release at 0.58 nM) Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.11 additional information D609 has no effect Sus scrofa
3.1.4.11 U73122 effectively blocks the effect of insulin on the release of GPI-renal dipeptidase Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.11 Ca2+
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Sus scrofa
-
-
-
3.4.13.19 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 kidney
-
 Sus scrofa
-
3.1.4.11 proximal tubule
-
 Sus scrofa
-
3.4.13.19 proximal tubule
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 GPI-renal dipeptidase
-
 Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 GPI-PLC
-
 Sus scrofa
3.1.4.11 GPI-specific phospholipase C
-
 Sus scrofa
3.4.13.19 GPI-renal dipeptidase
-
 Sus scrofa
3.4.13.19 RDPase
-
 Sus scrofa