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Literature summary extracted from

  • Shoji, N.; Yoshida, A.; Yu, Z.; Endo, Y.; Sasano, T.
    Lipopolysaccharide stimulates histamine-forming enzyme (histidine decarboxylase) activity in murine dental pulp and gingiva (2006), Arch. Oral Biol., 51, 856-860.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.22 lipopolysaccharide excreted from Escherichia coli after oral infection, stimulates the enzyme in dental pulp and gingiva, tissue-specific effects, oveview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Mus musculus
-
 histamine + CO2
-
 ?
4.1.1.22 additional information Mus musculus mast cells are known to produce histamine through a difference mechanism than HDC induction ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Mus musculus
-
 male BALB/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 dental pulp
-
 Mus musculus
-
4.1.1.22 ear ear skin Mus musculus
-
4.1.1.22 gingiva
-
 Mus musculus
-
4.1.1.22 liver
-
 Mus musculus
-
4.1.1.22 skin ear skin Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.22 additional information
-
 tissue-specific activity induced by lipopolysaccharide, overview Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Mus musculus histamine + CO2
-
 ?
4.1.1.22 additional information mast cells are known to produce histamine through a difference mechanism than HDC induction Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Mus musculus
4.1.1.22 histamine-forming enzyme
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.22 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 6.7
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate
-
 Mus musculus