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Literature summary extracted from
- Mitochondrial metabolism of 17alpha-hydroxyprogesterone in male sea bass (Dicentrarchus labrax): a potential target for endocrine disruptors (2007), Aquat. Toxicol., 85, 258-266.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.32 | 4-nonylphenol | strong inhibitory effect at 0.1 mM | Dicentrarchus labrax |  |
| 1.14.14.32 | ketoconazole | strong inhibitory effect at 0.1 mM | Dicentrarchus labrax | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.32 | mitochondrion | - |
Dicentrarchus labrax | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.32 | Dicentrarchus labrax | - |
sea bass | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.32 | 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Dicentrarchus labrax | androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.32 | C17,20-lyase | - |
Dicentrarchus labrax |
| 1.14.14.32 | CYP17 | - |
Dicentrarchus labrax |
| 1.14.14.32 | P450c17 | - |
Dicentrarchus labrax |
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Release 2023.1 (January 2023)
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