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Literature summary extracted from

  • Li, X.; Molina-Molina, M.; Abdul-Hafez, A.; Uhal, V.; Xaubet, A.; Uhal, B.D.
    Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis (2008), Am. J. Physiol. Lung Cell Mol. Physiol., 295, L178-185.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.17.23 medicine ACE-2 protects against lung fibrogenesis by limiting the local accumulation of the profibrotic peptide angiotensin II Mus musculus
3.4.17.23 medicine ACE-2 protects against lung fibrogenesis by limiting the local accumulation of the profibrotic peptide angiotensin II Homo sapiens
3.4.17.23 medicine ACE-2 protects against lung fibrogenesis by limiting the local accumulation of the profibrotic peptide angiotensin II Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 DX600 competitive inhibitor, 0.1 mM Homo sapiens
3.4.17.23 DX600 competitive inhibitor, 0.1 mM Mus musculus
3.4.17.23 DX600 competitive inhibitor, 0.1 mM Rattus norvegicus
3.4.17.23 additional information ACE-2 mRNA and activity are severely downregulated in lung fibrosis Homo sapiens
3.4.17.23 additional information ACE-2 mRNA and activity are severely downregulated in lung fibrosis Mus musculus
3.4.17.23 additional information ACE-2 mRNA and activity are severely downregulated in lung fibrosis Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens
-
-
-
3.4.17.23 Mus musculus
-
-
-
3.4.17.23 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 (7-methoxycoumarin-4-yl)-acetyl-YVADAPK-(2,4-dinitrophenyl)-OH + H2O
-
 Mus musculus (7-methoxycoumarin-4-yl)-acetyl-YVADAP + N6-(2,4-dinitrophenyl)-L-Lys
-
 ?
3.4.17.23 (7-methoxycoumarin-4-yl)-acetyl-YVADAPK-(2,4-dinitrophenyl)-OH + H2O
-
 Homo sapiens (7-methoxycoumarin-4-yl)-acetyl-YVADAP + N6-(2,4-dinitrophenyl)-L-Lys
-
 ?
3.4.17.23 (7-methoxycoumarin-4-yl)-YVADAPK-(2,4-dinitrophenyl)-OH + H2O
-
 Rattus norvegicus (7-methoxycoumarin-4-yl)-YVADAP + N6-(2,4-dinitrophenyl)-L-lysine
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Mus musculus angiotensin-(1-7) + Phe
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Homo sapiens angiotensin-(1-7) + Phe
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Rattus norvegicus angiotensin-(1-7) + Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE-2
-
 Mus musculus
3.4.17.23 ACE-2
-
 Homo sapiens
3.4.17.23 ACE-2
-
 Rattus norvegicus
3.4.17.23 angiotensin converting enzyme-2
-
 Mus musculus
3.4.17.23 angiotensin converting enzyme-2
-
 Homo sapiens
3.4.17.23 angiotensin converting enzyme-2
-
 Rattus norvegicus