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Literature summary extracted from

  • Deschamps, A.M.; Zavadzkas, J.; Murphy, R.L.; Koval, C.N.; McLean, J.E.; Jeffords, L.; Saunders, S.M.; Sheats, N.J.; Stroud, R.E.; Spinale, F.G.
    Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion (2008), Am. J. Physiol. Heart Circ. Physiol., 294, H875-H883.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.80 endothelin
-
 Sus scrofa
3.4.24.80 Protein kinase C
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.80 membrane
-
 Sus scrofa 16020
-
3.4.24.80 membrane the enzyme is a membrane type 1 protein Sus scrofa 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.80 additional information Sus scrofa MT1-MMP is increased in myocardial ischemia and reperfusion, and contributes to myocardial dysfunction, upstream induction mechanism by release of endothelin and protein kinase C activation, microdialysis analysis, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.80 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.80 endothelial cell
-
 Sus scrofa
-
3.4.24.80 heart MT1-MMP is increased in myocardial ischemia and reperfusion, myocardial, interstitial enzyme, microdialysis analysis, overview Sus scrofa
-
3.4.24.80 myocardium
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.80 (7-methoxycoumarin-4-yl)-acetyl-Pro-Leu-Ala-Cys(p-OmeBz)-Trp-Ala-Arg(Dpa)-NH2 + H2O
-
 Sus scrofa ?
-
 ?
3.4.24.80 additional information MT1-MMP is increased in myocardial ischemia and reperfusion, and contributes to myocardial dysfunction, upstream induction mechanism by release of endothelin and protein kinase C activation, microdialysis analysis, overview Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.80 interstitial MT1-MMP
-
 Sus scrofa
3.4.24.80 membrane type 1 matrix metalloproteinase
-
 Sus scrofa
3.4.24.80 MT1-MMP
-
 Sus scrofa