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Literature summary extracted from

  • Akiba, Y.; Mizumori, M.; Guth, P.H.; Engel, E.; Kaunitz, J.D.
    Duodenal brush border intestinal alkaline phosphatase activity affects bicarbonate secretion in rats (2007), Am. J. Physiol. Gastrointest. Liver Physiol., 293, G1223-G1233.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.1 analysis development of a simple in situ duodenal alkaline phosphatase activity assay based on the fluorogenic substrate ELF Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.1 D-Cys 10 mM Rattus norvegicus
3.1.3.1 glycerol phosphate
-
 Rattus norvegicus
3.1.3.1 L-Cys
-
 Rattus norvegicus
3.1.3.1 L-Phe maximal ainhibition at 1 mM. D-Phe has no effect Rattus norvegicus
3.1.3.1 levamisole inhibits brush border membrane enzyme activity in the upper villus but is less effective in the middle villus and has no effect on alkaline phosphatase activity in the mucus gel Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.1 duodenum villous surface. HCO3- secretion increases alkaline phosphatase activity by increasing local pH at its catalytic site. Alkaline phosphatase hydrolyzes luminal phosphates, presumably ATP, which increases HCO3- secretion via activation of P2 receptors Rattus norvegicus
-

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.1 7 8.5
-
 Rattus norvegicus