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Literature summary extracted from

  • Vinciguerra, M.; Mordasini, D.; Vandewalle, A.; Feraille, E.
    Hormonal and nonhormonal mechanisms of regulation of the NA,K-pump in collecting duct principal cells (2005), Semin. Nephrol., 25, 312-321.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.2.2.13 aldosterone control of Na,K-ATPase activity and expression Mammalia
7.2.2.13 Insulin control of Na,K-ATPase activity and expression Mammalia
7.2.2.13 sodium control of Na,K-ATPase activity and expression by intracellular Na+ Mammalia
7.2.2.13 Vasopressin control of Na,K-ATPase activity and expression Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 alpha2-adrenergic agonists negative modulator Mammalia
7.2.2.13 bradykinin negative modulator Mammalia
7.2.2.13 dopamine negative modulator Mammalia
7.2.2.13 endothelin negative modulator Mammalia
7.2.2.13 Prostaglandins negative modulator Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.13 membrane
-
 Mammalia 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.13 ADP + phosphate + Na+/out Mammalia each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP ATP + H2O + Na+/in
-
 ?
7.2.2.13 ATP + H2O + K+/in Mammalia
-
 ADP + phosphate + K+/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.13 collecting duct
-
 Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ADP + phosphate + Na+/out
-
 Mammalia ATP + H2O + Na+/in
-
 ?
7.2.2.13 ADP + phosphate + Na+/out each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP Mammalia ATP + H2O + Na+/in
-
 ?
7.2.2.13 ATP + H2O + K+/in
-
 Mammalia ADP + phosphate + K+/out
-
 ?

Subunits

EC Number Subunits Comment Organism
7.2.2.13 heterodimer alphabeta Mammalia

Synonyms

EC Number Synonyms Comment Organism
7.2.2.13 Na,K-adenosine triphosphatase
-
 Mammalia
7.2.2.13 Na,K-ATPase
-
 Mammalia
7.2.2.13 Na,K-Pump
-
 Mammalia
7.2.2.13 sodium pump
-
 Mammalia