Any feedback?
Literature summary extracted from
- Stimulatory effect of LH, PGE2 and progesterone on StAR protein, cytochrome P450 cholesterol side chain cleavage and 3beta hydroxysteroid dehydrogenase gene expression in bovine luteal cells (2005), Prostaglandins other Lipid Mediat., 78, 169-184.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.15.6 | additional information | luteinizing hormone, progesterone, and prostaglandin E2 induce enzyme expression in luteal cells | Bos taurus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.15.6 | additional information | S-nitroso-N-acetylpenicillamine inhibits enzyme transcription and translation in luteal cells | Bos taurus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.6 | cholesterol + reduced ferredoxin + O2 | Bos taurus | metabolic regulation of enzyme expression, overview | pregnenolone + 4-methylpentanal + oxidized ferredoxin | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.15.6 | Bos taurus | - |
female | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.15.6 | corpus luteum | primary, from corpora lutea at day 6 to 10 of the estrous cycle, semi-quatitative enzyme expression analysis | Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.6 | cholesterol + reduced ferredoxin + O2 | - |
Bos taurus | pregnenolone + 4-methylpentanal + oxidized ferredoxin | - |
? | |
| 1.14.15.6 | cholesterol + reduced ferredoxin + O2 | metabolic regulation of enzyme expression, overview | Bos taurus | pregnenolone + 4-methylpentanal + oxidized ferredoxin | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.15.6 | cytochrome P450 cholesterol side chain cleavage | - |
Bos taurus |
| 1.14.15.6 | P450scc | - |
Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.15.6 | Ferredoxin | - |
Bos taurus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
