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Literature summary extracted from

  • Cao, J.; Li, J.L.; Li, D.; Tobin, J.F.; Gimeno, R.E.
    Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis (2006), Proc. Natl. Acad. Sci. USA, 103, 19695-19700.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.15 medicine GPAT3 may be useful as a target for the treatment of obesity Mus musculus
2.3.1.15 medicine GPAT3 may be useful as a target for the treatment of obesity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.15 GPAT3 is localized to the endoplasmic reticulum when overexpressed in COS-7 cells Mus musculus
2.3.1.15 GPAT3 is localized to the endoplasmic reticulum when overexpressed in COS-7 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.15 endoplasmic reticulum
-
 Mus musculus 5783
-
2.3.1.15 endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate Mus musculus key enzyme in de novo triacylglycerol synthesis CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate Homo sapiens key enzyme in de novo triacylglycerol synthesis CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.15 Homo sapiens
-
-
-
2.3.1.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.15 adipocyte GPAT3 mRNA is dramatically upregulated during adipocyte differentiation Mus musculus
-
2.3.1.15 adipocyte GPAT3 mRNA is dramatically upregulated during adipocyte differentiation Homo sapiens
-
2.3.1.15 adipose tissue
-
 Homo sapiens
-
2.3.1.15 brown adipose tissue
-
 Mus musculus
-
2.3.1.15 colon
-
 Mus musculus
-
2.3.1.15 heart
-
 Mus musculus
-
2.3.1.15 heart
-
 Homo sapiens
-
2.3.1.15 kidney
-
 Mus musculus
-
2.3.1.15 kidney
-
 Homo sapiens
-
2.3.1.15 lung
-
 Homo sapiens
-
2.3.1.15 skeletal muscle
-
 Homo sapiens
-
2.3.1.15 small intestine
-
 Mus musculus
-
2.3.1.15 testis
-
 Homo sapiens
-
2.3.1.15 thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate key enzyme in de novo triacylglycerol synthesis Mus musculus CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 acyl-CoA + sn-glycerol 3-phosphate key enzyme in de novo triacylglycerol synthesis Homo sapiens CoA + 1-acyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 lauroyl-CoA + sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-lauroyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 lauroyl-CoA + sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-lauroyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.15 ER-associated GPAT
-
 Mus musculus
2.3.1.15 ER-associated GPAT
-
 Homo sapiens
2.3.1.15 GPAT3
-
 Mus musculus
2.3.1.15 GPAT3
-
 Homo sapiens