EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.1.104 | medicine | plays a role in the biosynthesis of curcuminoids, which are important pharmacologically active metabolites | Curcuma longa |
2.1.1.104 | medicine | plays a role in the biosynthesis of gingerols, which are important pharmacologically active metabolites | Zingiber officinale |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.99 | additional information | Curcuma longa | analysis of enzymes involved in biosynthesis of curcuminoids | ? | - |
? | |
2.3.1.99 | additional information | Zingiber officinale | analysis of enzymes involved in biosynthesis of ginger | ? | - |
? | |
2.3.1.133 | 4-coumaroyl-CoA + shikimate | Zingiber officinale | - |
CoA + 5-O-(4-coumaroyl)shikimate | - |
? | |
2.3.1.133 | 4-coumaroyl-CoA + shikimate | Curcuma longa | - |
CoA + 5-O-(4-coumaroyl)shikimate | - |
? | |
2.3.1.133 | additional information | Zingiber officinale | the enzyme is involved in the phenylpropanoid pathway and the biosynthesis of curcuminoids and in lignification, the enzyme activity is modulated in plants as a mechanism to control production of specific metabolites, overview | ? | - |
? | |
2.3.1.133 | additional information | Curcuma longa | the enzyme is involved in the phenylpropanoid pathway and the biosynthesis of curcuminoids and in lignification, the enzyme activity is modulated in plants as a mechanism to control production of specific metabolites, overview | ? | - |
? | |
2.3.1.211 | 2 4-coumaroyl-CoA + malonyl-CoA + H2O | Curcuma longa | - |
3 CoA + bisdemethoxycurcumin + 2 CO2 | - |
? | |
2.3.1.211 | additional information | Curcuma longa | the curcuminoid synthase might also use feruloyl-CoA as substrate, via demethoxycurcumin, to curcumin, possible pathway overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.104 | Curcuma longa | - |
- |
- |
2.1.1.104 | Zingiber officinale | - |
- |
- |
2.3.1.99 | Curcuma longa | - |
- |
- |
2.3.1.99 | Zingiber officinale | - |
- |
- |
2.3.1.133 | Curcuma longa | - |
- |
- |
2.3.1.133 | Zingiber officinale | - |
- |
- |
2.3.1.211 | Curcuma longa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.104 | partially purified | Zingiber officinale |
2.1.1.104 | partially purified | Curcuma longa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.104 | leaf | - |
Zingiber officinale | - |
2.1.1.104 | leaf | - |
Curcuma longa | - |
2.1.1.104 | rhizome | - |
Zingiber officinale | - |
2.1.1.104 | rhizome | - |
Curcuma longa | - |
2.1.1.104 | shoot | - |
Zingiber officinale | - |
2.1.1.104 | shoot | - |
Curcuma longa | - |
2.3.1.99 | leaf | - |
Zingiber officinale | - |
2.3.1.99 | leaf | - |
Curcuma longa | - |
2.3.1.99 | rhizome | - |
Zingiber officinale | - |
2.3.1.99 | rhizome | - |
Curcuma longa | - |
2.3.1.99 | shoot | - |
Zingiber officinale | - |
2.3.1.99 | shoot | - |
Curcuma longa | - |
2.3.1.133 | leaf | - |
Zingiber officinale | - |
2.3.1.133 | leaf | - |
Curcuma longa | - |
2.3.1.133 | rhizome | - |
Zingiber officinale | - |
2.3.1.133 | rhizome | - |
Curcuma longa | - |
2.3.1.133 | shoot | 1.5-2.0fold higher enzyme activity compared to leaves and rhizomes | Curcuma longa | - |
2.3.1.133 | shoot | 1.6fold higher enzyme activity compared to leaves and rhizomes | Zingiber officinale | - |
2.3.1.211 | leaf | highest activity | Curcuma longa | - |
2.3.1.211 | rhizome | - |
Curcuma longa | - |
2.3.1.211 | shoot | - |
Curcuma longa | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.1.133 | additional information | - |
- |
Zingiber officinale |
2.3.1.133 | additional information | - |
- |
Curcuma longa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.104 | S-adenosyl-L-methionine + caffeoyl-CoA | - |
Zingiber officinale | S-adenosyl-L-homocysteine + feruloyl-CoA | - |
? | |
2.1.1.104 | S-adenosyl-L-methionine + caffeoyl-CoA | - |
Curcuma longa | S-adenosyl-L-homocysteine + feruloyl-CoA | - |
? | |
2.3.1.99 | 4-coumaroyl-CoA + quinate | - |
Zingiber officinale | CoA + 5-O-(4-coumaroyl)quinate | - |
? | |
2.3.1.99 | 4-coumaroyl-CoA + quinate | - |
Curcuma longa | CoA + 5-O-(4-coumaroyl)quinate | - |
? | |
2.3.1.99 | caffeoyl-CoA + quinate | - |
Zingiber officinale | CoA + 5-O-caffeoylquinate | - |
? | |
2.3.1.99 | caffeoyl-CoA + quinate | - |
Curcuma longa | CoA + 5-O-caffeoylquinate | - |
? | |
2.3.1.99 | feruloyl-CoA + quinate | - |
Zingiber officinale | CoA + O-feruloylquinate | - |
? | |
2.3.1.99 | feruloyl-CoA + quinate | - |
Curcuma longa | CoA + O-feruloylquinate | - |
? | |
2.3.1.99 | additional information | analysis of enzymes involved in biosynthesis of curcuminoids | Curcuma longa | ? | - |
? | |
2.3.1.99 | additional information | analysis of enzymes involved in biosynthesis of ginger | Zingiber officinale | ? | - |
? | |
2.3.1.133 | 4-coumaroyl-CoA + shikimate | - |
Zingiber officinale | CoA + 5-O-(4-coumaroyl)shikimate | - |
? | |
2.3.1.133 | 4-coumaroyl-CoA + shikimate | - |
Curcuma longa | CoA + 5-O-(4-coumaroyl)shikimate | - |
? | |
2.3.1.133 | 4-coumaroyl-CoA + shikimate | - |
Zingiber officinale | CoA + 5-O-(4-coumaroyl)shikimate | product determination | ? | |
2.3.1.133 | 4-coumaroyl-CoA + shikimate | - |
Curcuma longa | CoA + 5-O-(4-coumaroyl)shikimate | product determination | ? | |
2.3.1.133 | additional information | the enzyme is involved in the phenylpropanoid pathway and the biosynthesis of curcuminoids and in lignification, the enzyme activity is modulated in plants as a mechanism to control production of specific metabolites, overview | Zingiber officinale | ? | - |
? | |
2.3.1.133 | additional information | the enzyme is involved in the phenylpropanoid pathway and the biosynthesis of curcuminoids and in lignification, the enzyme activity is modulated in plants as a mechanism to control production of specific metabolites, overview | Curcuma longa | ? | - |
? | |
2.3.1.211 | 2 4-coumaroyl-CoA + malonyl-CoA + H2O | - |
Curcuma longa | 3 CoA + bisdemethoxycurcumin + 2 CO2 | - |
? | |
2.3.1.211 | additional information | the curcuminoid synthase might also use feruloyl-CoA as substrate, via demethoxycurcumin, to curcumin, possible pathway overview | Curcuma longa | ? | - |
? | |
2.3.1.211 | additional information | curcuminoid synthase activity shows a requirement for both 4-coumaroyl-CoA and feruloyl-CoA to be present in the activity assay in order for any product to be observed | Curcuma longa | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.104 | CCOMT | - |
Zingiber officinale |
2.1.1.104 | CCOMT | - |
Curcuma longa |
2.3.1.133 | CST | - |
Zingiber officinale |
2.3.1.133 | CST | - |
Curcuma longa |
2.3.1.133 | p-coumaroyl shikimate transferase | - |
Zingiber officinale |
2.3.1.133 | p-coumaroyl shikimate transferase | - |
Curcuma longa |
2.3.1.133 | p-coumaroyl-CoA:5-O-shikimate p-coumaroyl transferase | - |
Zingiber officinale |
2.3.1.133 | p-coumaroyl-CoA:5-O-shikimate p-coumaroyl transferase | - |
Curcuma longa |
2.3.1.211 | curcuminoid synthase | - |
Curcuma longa |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.133 | 37 | - |
assay at | Zingiber officinale |
2.3.1.133 | 37 | - |
assay at | Curcuma longa |
2.3.1.211 | 28 | - |
assay at | Curcuma longa |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.133 | 7 | - |
assay at | Zingiber officinale |
2.3.1.133 | 7 | - |
assay at | Curcuma longa |
2.3.1.211 | 8 | - |
assay at | Curcuma longa |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.211 | metabolism | the enzyme is involved in the phenylpropanoid pathway. Thioesterase activities in Curcuma longa that cleave phenylpropanoid pathway CoA esters, are present at high levels in all tissues and may shunt phenylpropanoid pathway intermediates away from the production of curcuminoids and gingerols, thereby potentially playing a regulatory role in the biosynthesis of these compounds | Curcuma longa |