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Literature summary extracted from

  • Sigmond, J.; Haveman, J.; Kreder, N.C.; Loves, W.J.; van Bree, C.; Franken, N.A.; Peters, G.J.
    Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation (2006), Nucleosides Nucleotides Nucleic Acids, 25, 1177-1180.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.74 additional information irradiation of intact cells increases enzyme activity, upregulation of activity might be caused by phosphorylation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 additional information Homo sapiens essential for the synthesis of deoxynucleotides required for DNA repair and involved in deoxynucleoside analogue activation ?
-
 ?
2.7.1.74 NTP + 2',2'-difluorodeoxycytidine Homo sapiens substrate also termed gemcitabine NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.74 additional information irradiation induced phosphorylation suggested to be involved in the regulation of enzyme activity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 SW-1573 cell cells irradiated in the late exponential growth phase for experiments Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 additional information essential for the synthesis of deoxynucleotides required for DNA repair and involved in deoxynucleoside analogue activation Homo sapiens ?
-
 ?
2.7.1.74 NTP + 2',2'-difluorodeoxycytidine substrate also termed gemcitabine Homo sapiens NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
 ?
2.7.1.74 NTP + 2-chloro-2'-deoxyadenosine
-
 Homo sapiens NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens