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Literature summary extracted from

  • Sampson, S.R.; Cooper, D.R.
    Specific protein kinase C isoforms as transducers and modulators of insulin signaling (2006), Mol. Genet. Metab., 89, 32-47.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.13 fatty acids activation mechanism Mus musculus
2.7.11.13 fatty acids activation mechanism Homo sapiens
2.7.11.13 fatty acids activation mechanism, isozyme PKCdelta is involved in fatty acid-induced hepatic insulin resistance Rattus norvegicus
2.7.11.13 Insulin activates PKC isozymes alpha, betaII, delta, and zeta in several cell types, activation mechanism Mus musculus
2.7.11.13 Insulin activates PKC isozymes alpha, betaII, delta, and zeta in several cell types, activation mechanism Homo sapiens
2.7.11.13 Insulin activates PKC isozymes alpha, betaII, delta, and zeta in several cell types, activation mechanism, isozyme PKCdelta is involved in fatty acid-induced hepatic insulin resistance Rattus norvegicus
2.7.11.13 palmitate activates isozyme PKCtheta, but not isozymes PKCalpha and PKCepsilon Rattus norvegicus
2.7.11.13 phosphatidylserine activation mechanism Mus musculus
2.7.11.13 phosphatidylserine activation mechanism Homo sapiens
2.7.11.13 phosphatidylserine activation mechanism Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.13 co-expression of PKC isozymes and insulin in HEK-293 or CHO cells, interaction analysis, overview Mus musculus
2.7.11.13 co-expression of PKC isozymes and insulin in HEK-293 or CHO cells, interaction analysis, overview Homo sapiens
2.7.11.13 co-expression of PKC isozymes and insulin in HEK-293 or CHO cells, interaction analysis, overview Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.13 CG53353 inhibitor of isozyme PKCbetaII Homo sapiens
2.7.11.13 CG53353 inhibitor of isozyme PKCbetaII Mus musculus
2.7.11.13 CG53353 inhibitor of isozyme PKCbetaII Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.13 Ca2+ activation mechanism Mus musculus
2.7.11.13 Ca2+ activation mechanism Homo sapiens
2.7.11.13 Ca2+ activation mechanism Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.13 additional information Mus musculus regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview ?
-
?
2.7.11.13 additional information Homo sapiens regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview ?
-
?
2.7.11.13 additional information Rattus norvegicus regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview, isozyme PKCepsilon forms signaling complexes with Raf-1 and ERK, isozyme PKCtheta inactivation prevents fat-induced defects in insulin signaling and glucose transport in skeletal muscle ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Homo sapiens
-
conventional, novel, and atypical isozyme types, overview
-
2.7.11.13 Mus musculus
-
conventional, novel, and atypical isozyme types, overview
-
2.7.11.13 Rattus norvegicus
-
conventional, novel, and atypical isozyme types, overview
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.13 adipocyte
-
Mus musculus
-
2.7.11.13 adipocyte
-
Homo sapiens
-
2.7.11.13 adipocyte
-
Rattus norvegicus
-
2.7.11.13 adipose tissue
-
Mus musculus
-
2.7.11.13 adipose tissue
-
Homo sapiens
-
2.7.11.13 adipose tissue
-
Rattus norvegicus
-
2.7.11.13 brain
-
Mus musculus
-
2.7.11.13 brain
-
Homo sapiens
-
2.7.11.13 brain
-
Rattus norvegicus
-
2.7.11.13 cell culture primary Mus musculus
-
2.7.11.13 cell culture primary Homo sapiens
-
2.7.11.13 cell culture primary Rattus norvegicus
-
2.7.11.13 fibroblast
-
Mus musculus
-
2.7.11.13 fibroblast
-
Homo sapiens
-
2.7.11.13 fibroblast
-
Rattus norvegicus
-
2.7.11.13 H4IIE cell
-
Rattus norvegicus
-
2.7.11.13 hepatoma cell constitutively active isozyme PKCdelta Rattus norvegicus
-
2.7.11.13 liver
-
Mus musculus
-
2.7.11.13 liver
-
Homo sapiens
-
2.7.11.13 liver
-
Rattus norvegicus
-
2.7.11.13 myotube isozyme PKCbetaII Mus musculus
-
2.7.11.13 myotube isozyme PKCbetaII Homo sapiens
-
2.7.11.13 myotube isozyme PKCbetaII Rattus norvegicus
-
2.7.11.13 NIH-3T3 cell
-
Mus musculus
-
2.7.11.13 skeletal muscle
-
Mus musculus
-
2.7.11.13 skeletal muscle
-
Homo sapiens
-
2.7.11.13 skeletal muscle isozyme PKCtheta is decreased in obese patients' skeletal muscle Rattus norvegicus
-
2.7.11.13 white muscle increased expresison of isozyme PKCtheta in insulin-resistant rats Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 ATP + Akt phosphorylation on Ser473 by isozyme PKCbetaII Mus musculus ADP + phosphorylated Akt
-
?
2.7.11.13 ATP + Akt phosphorylation on Ser473 by isozyme PKCbetaII Homo sapiens ADP + phosphorylated Akt
-
?
2.7.11.13 ATP + Akt phosphorylation on Ser473 by isozyme PKCbetaII Rattus norvegicus ADP + phosphorylated Akt
-
?
2.7.11.13 ATP + insulin receptor isozyme PKCalpha Mus musculus ADP + phosphorylated insulin receptor
-
?
2.7.11.13 ATP + insulin receptor isozyme PKCalpha Homo sapiens ADP + phosphorylated insulin receptor
-
?
2.7.11.13 ATP + insulin receptor isozyme PKCalpha Rattus norvegicus ADP + phosphorylated insulin receptor
-
?
2.7.11.13 ATP + IRS isozymes PKCalpha and PKCdelta, phosphorylation on Ser307 Mus musculus ADP + phosphorylated IRS
-
?
2.7.11.13 ATP + IRS isozymes PKCalpha and PKCdelta, phosphorylation on Ser307 Homo sapiens ADP + phosphorylated IRS
-
?
2.7.11.13 ATP + IRS isozymes PKCalpha and PKCdelta, phosphorylation on Ser307 Rattus norvegicus ADP + phosphorylated IRS
-
?
2.7.11.13 additional information regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview Mus musculus ?
-
?
2.7.11.13 additional information regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview Homo sapiens ?
-
?
2.7.11.13 additional information regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview, isozyme PKCepsilon forms signaling complexes with Raf-1 and ERK, isozyme PKCtheta inactivation prevents fat-induced defects in insulin signaling and glucose transport in skeletal muscle Rattus norvegicus ?
-
?
2.7.11.13 additional information PKCbetaII specifically binds to beta-actin Mus musculus ?
-
?
2.7.11.13 additional information PKCbetaII specifically binds to beta-actin Homo sapiens ?
-
?
2.7.11.13 additional information PKCbetaII specifically binds to beta-actin Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKC
-
Mus musculus
2.7.11.13 PKC
-
Homo sapiens
2.7.11.13 PKC
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.13 ATP
-
Mus musculus
2.7.11.13 ATP
-
Homo sapiens
2.7.11.13 ATP
-
Rattus norvegicus