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Literature summary extracted from

  • Lukacik, P.; Kavanagh, K.L.; Oppermann, U.
    Structure and function of human 17beta-hydroxysteroid dehydrogenases (2006), Mol. Cell. Endocrinol., 248, 61-71.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.62 drug development several 17beta-HSD isozymes are targets for drug development with importance in cancer, metabolic diseases, neurodegeneration and possibly immunity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.62 chromosomal localizations of isozymes, DNA and amino acid sequence determination and analysis of isozymes 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, overview Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.62 17beta-HSD14 in ternary complex with NADP+ and estradiol, modelling Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.51 endoplasmic reticulum the hydrophobic 17beta-HSD3 is membrane-bound through an N-terminal transmembrane domain Homo sapiens 5783
-
1.1.1.62 endoplasmic reticulum isozymes 17beta-HSD2, 17beta-HSD3, and 17beta-HSD7 Homo sapiens 5783
-
1.1.1.62 mitochondrion isozyme 17beta-HSD10 Homo sapiens 5739
-
1.1.1.62 soluble isozyme 17beta-HSD14, 17beta-HSD5, and 17beta-HSD1 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 4-androstene-3,17-dione + NADPH + H+ Homo sapiens isozymes 17beta-HSD3 and 17beta-HSD5 testosterone + NADP+
-
 r
1.1.1.51 5-androstenedione + NADPH Homo sapiens isozyme 17beta-HSD3 5alpha-dihydrotestosterone + NADP+
-
 r
1.1.1.51 additional information Homo sapiens the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis ?
-
 ?
1.1.1.62 estrone + NADPH Homo sapiens the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites 17beta-estradiol + NADP+
-
 r
1.1.1.62 estronesulfate + NADPH Homo sapiens
-
 17beta-estradiolsulfate + NADP+
-
 r
1.1.1.62 additional information Homo sapiens the isozymes constitute by showing different properties a complex system ensuring cell-specific adaptation and regulation of sex steroid hormone levels, isozyme 17beta-HSD1 is the major determinant of peripheral and gonadal estradiol synthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
 isozymes 17beta-HSD3 and 17beta-HSD5
-
1.1.1.62 Homo sapiens
-
 several isozymes, encoded by different genes
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.62 17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ active site structure of isozymes 17beta-HSD1 and 17beta-HSD14 Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 adrenal gland isozyme 17beta-HSD5 Homo sapiens
-
1.1.1.51 gonad isozymes 17beta-HSD3 and 17beta-HSD5 Homo sapiens
-
1.1.1.51 liver isozyme 17beta-HSD5 Homo sapiens
-
1.1.1.51 prostate gland isozyme 17beta-HSD5 Homo sapiens
-
1.1.1.51 testis high expression level of isozyme 17beta-HSD5 Homo sapiens
-
1.1.1.62 gonad
-
 Homo sapiens
-
1.1.1.62 liver 17beta-HSD8 Homo sapiens
-
1.1.1.62 ovary 17beta-HSD8 in cumulus cells, not in granulosa and luteal cells, vice versa for isozymes 17beta-HSD1 and 17beta-HSD7 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 4-androstene-3,17-dione + NADPH + H+ isozymes 17beta-HSD3 and 17beta-HSD5 Homo sapiens testosterone + NADP+
-
 r
1.1.1.51 5-androstenedione + NADPH isozyme 17beta-HSD3 Homo sapiens 5alpha-dihydrotestosterone + NADP+
-
 r
1.1.1.51 additional information the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis Homo sapiens ?
-
 ?
1.1.1.51 additional information isozyme 17beta-HSD5 also shows 3alpha- and 20alpha-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase, and prostaglandin synthase activities Homo sapiens ?
-
 ?
1.1.1.62 estrone + NADPH the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites Homo sapiens 17beta-estradiol + NADP+
-
 r
1.1.1.62 estrone + NADPH substrate of e.g. isozyme 17beta-HSD3, 17beta-HSD8, and 17beta-HSD14 Homo sapiens 17beta-estradiol + NADP+
-
 r
1.1.1.62 estronesulfate + NADPH
-
 Homo sapiens 17beta-estradiolsulfate + NADP+
-
 r
1.1.1.62 additional information the isozymes constitute by showing different properties a complex system ensuring cell-specific adaptation and regulation of sex steroid hormone levels, isozyme 17beta-HSD1 is the major determinant of peripheral and gonadal estradiol synthesis Homo sapiens ?
-
 ?
1.1.1.62 additional information 17beta-HSD isozymes differ in their expression pattern, nucleotide cofactor preferences, steroid substrate specificity, and subcellular localization, detailed overview, substrate are androgens, estrogens, cholesterol, progestins, and eicosanoids, isozyme 17beta-HSD3 also shows 3beta-hydroxysteroid dehydrogenase, EC 1.1.1.51, isozyme 17beta-HSD8 also shows, to a lessser extent, NAD+-dependent testosterone oxidation to androstenedione, EC 1.1.1.63 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-HSD3
-
 Homo sapiens
1.1.1.51 17beta-HSD5
-
 Homo sapiens
1.1.1.62 17beta-HSD
-
 Homo sapiens
1.1.1.62 17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.62 More 17beta-HSDs belong to the aldo-keto reductase family or the short-chain dehydrogenase family, overview Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADPH dependent on Homo sapiens
1.1.1.62 NADP+
-
 Homo sapiens
1.1.1.62 NADPH
-
 Homo sapiens