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Literature summary extracted from
- Expression of cytochrome P-450 4 enzymes in the kidney and liver: regulation by PPAR and species-difference between rat and human (2006), Mol. Cell. Biochem., 284, 141-148.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.1 | microsome | - |
Homo sapiens | - |
- |
| 1.14.14.1 | microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.1 | arachidonic acid + O2 + NADPH | Homo sapiens | - |
20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb | ? |  |
| 1.14.14.1 | arachidonic acid + O2 + NADPH | Rattus norvegicus | - |
20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb | ? | |
| 1.14.14.1 | additional information | Homo sapiens | the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview | ? | - |
? | |
| 1.14.14.1 | additional information | Rattus norvegicus | the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview, PPARalpha agonist increased the transcription activity of rat CYP4A1 | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.1 | Homo sapiens | - |
several isozymes, e.g. CYP4F and CYP4A | - |
| 1.14.14.1 | Rattus norvegicus | - |
several isozymes, e.g. CYP4F and CYP4A, 9-week-old, male Sprague-Dawley rats | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.14.1 | partially by microsome preparation | Homo sapiens |
| 1.14.14.1 | partially by microsome preparation | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.1 | kidney | especially in proximal tubule, lower expression in the preglomerular microvessel, glomerulus and thick ascending limb | Homo sapiens | - |
| 1.14.14.1 | kidney | especially in proximal tubule, lower expression in the preglomerular microvessel, glomerulus and thick ascending limb | Rattus norvegicus | - |
| 1.14.14.1 | liver | - |
Homo sapiens | - |
| 1.14.14.1 | liver | - |
Rattus norvegicus | - |
| 1.14.14.1 | additional information | isozyme tissue-specific expression analysis, regulation by PPAR | Homo sapiens | - |
| 1.14.14.1 | additional information | isozyme tissue-specific expression analysis, regulation by PPAR | Rattus norvegicus | - |
| 1.14.14.1 | renal cortex | - |
Homo sapiens | - |
| 1.14.14.1 | renal cortex | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.1 | arachidonic acid + O2 + NADPH | - |
Homo sapiens | 20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb | ? | |
| 1.14.14.1 | arachidonic acid + O2 + NADPH | - |
Rattus norvegicus | 20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e. 20-HETE, a potent constrictor of renal microvessels and inhibits Na+ reabsorption in the proximal tubule and thick ascending limb | ? | |
| 1.14.14.1 | arachidonic acid + O2 + NADPH | - |
Homo sapiens | 20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e.20-HETE | ? | |
| 1.14.14.1 | arachidonic acid + O2 + NADPH | - |
Rattus norvegicus | 20-hydroxyeicosatetraenoic acid + H2O + NADP+ | i.e.20-HETE | ? | |
| 1.14.14.1 | additional information | the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview | Homo sapiens | ? | - |
? | |
| 1.14.14.1 | additional information | the cytochrome P-450 4, CYP4, family catalyze the omega-hydroxylation of fatty acids, metabolic regulation, overview, PPARalpha agonist increased the transcription activity of rat CYP4A1 | Rattus norvegicus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.14.1 | ? | x * 50000-52000, CYP4A isoforms, SDS-PAGE | Homo sapiens |
| 1.14.14.1 | ? | x * 50000-52000, CYP4A isoforms, SDS-PAGE | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.1 | CYP4 | - |
Homo sapiens |
| 1.14.14.1 | CYP4 | - |
Rattus norvegicus |
| 1.14.14.1 | CYP4A | - |
Homo sapiens |
| 1.14.14.1 | CYP4A | - |
Rattus norvegicus |
| 1.14.14.1 | CYP4F | - |
Homo sapiens |
| 1.14.14.1 | CYP4F | - |
Rattus norvegicus |
| 1.14.14.1 | cytochrome P-450 4 enzyme | - |
Homo sapiens |
| 1.14.14.1 | cytochrome P-450 4 enzyme | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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