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Literature summary extracted from

  • Park, J.; Singh, B.; Gupta, R.S.
    Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives (2006), Mol. Cell. Biochem., 283, 11-21.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.20 acetyl phosphate 10 mM, activity is stimulated more than 10fold Cricetulus griseus
2.7.1.20 Carbamoyl phosphate 10 mM, activity is stimulated more than 10fold Cricetulus griseus
2.7.1.20 dihydroxyacetone phosphate 10 mM, activity is stimulated more than 10fold Cricetulus griseus
2.7.1.20 Imidodiphosphate
-
 Cricetulus griseus
2.7.1.20 phosphate 10 mM, activity is stimulated more than 10fold Cricetulus griseus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.20 expression in Escherichia coli Cricetulus griseus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.20 2-carboxyethylphosphonic acid
-
 Cricetulus griseus
2.7.1.20 clodronate inhibits adenosine kinase activity in a dose-dependent manner in the presence of 10 mM phosphate Cricetulus griseus
2.7.1.20 diethylphosphonoacetic acid
-
 Cricetulus griseus
2.7.1.20 etidronate inhibits adenosine kinase activity in a dose-dependent manner in the presence of 10 mM phosphate Cricetulus griseus
2.7.1.20 methylphosphonic acid
-
 Cricetulus griseus
2.7.1.20 N-(phosphonomethyl)-glycine
-
 Cricetulus griseus
2.7.1.20 N-(phosphonomethyl)iminodiacetic acid
-
 Cricetulus griseus
2.7.1.20 Phosphonoacetic acid
-
 Cricetulus griseus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Cricetulus griseus
-
 recombinant
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + adenosine
-
 Cricetulus griseus ADP + AMP
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.20 5.36
-
 etidronate
-
 Cricetulus griseus
2.7.1.20 7.19
-
 clodronate
-
 Cricetulus griseus