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Literature summary extracted from

  • Hankins, E.G.; Gillespie, J.R.; Aikenhead, K.; Buckner, F.S.
    Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors (2005), Mol. Biochem. Parasitol., 144, 68-75.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.154 additional information the lanosterol synthase inhibitor terbinafine and inhibition of squalene epoxidase and lanosterol synthase induce the transcription and translation of the enzyme about 7-12fold, upregulation is mediated through the 3'-untranslated region of the gene Trypanosoma cruzi

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.154 expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3), usage of the luciferase expression system Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.154 additional information Trypanosoma cruzi the organism can specifically regulate gene expression, e.g. for the sterol C14-demethylase, in response to derangements in its cellular functions ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Trypanosoma cruzi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.154 recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 additional information the organism can specifically regulate gene expression, e.g. for the sterol C14-demethylase, in response to derangements in its cellular functions Trypanosoma cruzi ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 sterol C14-demethylase
-
 Trypanosoma cruzi