Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Calderilla-Barbosa, L.; Ortega, A.; Cisneros, B.
    Phosphorylation of dystrophin Dp71d by Ca2+/calmodulin-dependent protein kinase II modulates the Dp71d nuclear localization in PC12 cells (2006), J. Neurochem., 98, 713-722.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 2-O-tetradecanoyl phorbol 13-acetate the activating effect is blocked by EGTA Rattus norvegicus
2.7.11.17 Calmodulin dependent on Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 overexpression of CaMKII isozyme alpha and truncated mutant CaMKII/290 in PC-12 cells Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 additional information overexpression of CaMKII favors the Dp71d nuclear accumulation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 KN62 a CaMKII-specific inhibitor Rattus norvegicus
2.7.11.17 N-(6-aminohexyl)-1-naphthalenesulfonamide i.e. W7, a calcium-calmodulin inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 nucleus CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization Rattus norvegicus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on, stimulation of calcium influx by cell depolarization increases Dp71d phosphorylation Rattus norvegicus
2.7.11.17 KCl KCl-induced cell depolarization stimulates Dp71d phosphorylation Rattus norvegicus
2.7.11.17 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + dystrophin Dp71d Rattus norvegicus the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization ADP + phosphorylated dystrophin Dp71d
-
 ?
2.7.11.17 additional information Rattus norvegicus CaMKII kinase modulates PC12 cell neuronal differentiation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 PC-12 cell a pheochromocytoma cell line, NGF-induced Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + dystrophin Dp71d the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization Rattus norvegicus ADP + phosphorylated dystrophin Dp71d
-
 ?
2.7.11.17 ATP + dystrophin Dp71d a nuclear splicing isoform of Dp71, several potential sites for phosphorylation Rattus norvegicus ADP + phosphorylated dystrophin Dp71d
-
 ?
2.7.11.17 additional information CaMKII kinase modulates PC12 cell neuronal differentiation Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 CaMKII
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus