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Literature summary extracted from
- Hydroxylated serotonin and dopamine as substrates and inhibitors for human cytosolic SULT1A3 (2007), J. Neurochem., 103, 2679-2689.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 2.8.2.1 | additional information | downregulation of SULT1A3 by siRNA in SK-N-MC cells abolishes the formation of 7-hydroxyserotonin and 6-hydroxydopamine | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.8.2.1 | 6-Hydroxydopamine | competiitve versus dopamine, complete inhibition at about 1 mM | Homo sapiens |  |
| 2.8.2.1 | 7-hydroxyserotonin | competitive versus serotonin, complete inhibition at about 1 mM | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.2.1 | additional information | - |
additional information | kinetics, SULT1A3 | Homo sapiens | |
| 2.8.2.1 | 0.007 | - |
dopamine | pH 7.0, 37°C, SULT1A3 | Homo sapiens | |
| 2.8.2.1 | 0.019 | - |
6-Hydroxydopamine | pH 7.0, 37°C, SULT1A3 | Homo sapiens | |
| 2.8.2.1 | 0.04 | - |
7-hydroxyserotonin | pH 7.0, 37°C, SULT1A3 | Homo sapiens | |
| 2.8.2.1 | 0.133 | - |
serotonin | pH 7.0, 37°C, SULT1A3 | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 2.8.2.1 | cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + 6-hydroxydopamine | Homo sapiens | SULT1A3 | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + 7-hydroxyserotonin | Homo sapiens | SULT1A3 | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + dopamine | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + serotonin | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | additional information | Homo sapiens | the enzyme plays an important role in the regulation and homeostasis of monoamine neurotransmitters, by serving as substrates for SULT1A3, 7-hydroxyserotonin or 6-hydroxydopamine may interfere with the homeostasis of endogenous serotonin and dopamine | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.8.2.1 | Homo sapiens | P0DMM9 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.8.2.1 | neuroblastoma cell | - |
Homo sapiens | - |
| 2.8.2.1 | SK-N-MC cell | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 2.8.2.1 | additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + 6-hydroxydopamine | SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + 6-hydroxydopamine | specific substrate of SULT1A3, no activity with other SULT isozymes | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + 7-hydroxyserotonin | SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + 7-hydroxyserotonin | specific substrate of SULT1A3, no activity with other SULT isozymes | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + dopamine | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + serotonin | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 2.8.2.1 | additional information | the enzyme plays an important role in the regulation and homeostasis of monoamine neurotransmitters, by serving as substrates for SULT1A3, 7-hydroxyserotonin or 6-hydroxydopamine may interfere with the homeostasis of endogenous serotonin and dopamine | Homo sapiens | ? | - |
? | |
| 2.8.2.1 | additional information | DOPA and 6-hydroxy-DOPA are poor substrates for SULT1A3 | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.8.2.1 | cytosolic sulfotransferase | - |
Homo sapiens |
| 2.8.2.1 | SULT1A3 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 2.8.2.1 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.8.2.1 | 7 | - |
with substrate 7-hydroxyserotonin | Homo sapiens |
| 2.8.2.1 | 8 | 9 | with substrates dopamine and 6-hydroxydopamine | Homo sapiens |
| 2.8.2.1 | 11 | - |
with substrate serotonin | Homo sapiens |
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