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Literature summary extracted from

  • Do Rego, J.L.; Tremblay, Y.; Luu-The, V.; Repetto, E.; Castel, H.; Vallarino, M.; Belanger, A.; Pelletier, G.; Vaudry, H.
    Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary (2007), J. Neurochem., 100, 251-268.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 ketoconazole
-
 Pelophylax lessonae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2 Pelophylax lessonae
-
 17alpha-hydroxypregnenolone + A + H2O
-
 ?
1.14.14.19 progesterone + AH2 + O2 Pelophylax lessonae
-
 17alpha-hydroxyprogesterone + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Pelophylax lessonae
-
-
-
1.14.14.19 Pelophylax lessonae
-
 male frogs
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.19 native enzyme partially from brain microsomes Pelophylax lessonae

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.19 brain telencephalon, diencephalon, mesencephalon, metencephalon. Immunoreactivity is almost exclusively located in neurons Pelophylax lessonae
-
1.14.14.19 brain distribution in the telencephalon, diencephalon, mesencephalon and metencephalon, detailed expression analysis, overview Pelophylax lessonae
-
1.14.14.19 diencephalon
-
 Pelophylax lessonae
-
1.14.14.19 metencephalon
-
 Pelophylax lessonae
-
1.14.14.19 pars distalis of pituitary Pelophylax lessonae
-
1.14.14.19 pars intermedia of pituitary Pelophylax lessonae
-
1.14.14.19 pituitary gland pars distalis, pars intermedia Pelophylax lessonae
-
1.14.14.19 pituitary gland in the pars distalis and pars intermedia of the pituitary, detailed expression analysis, overview Pelophylax lessonae
-
1.14.14.19 telencephalon
-
 Pelophylax lessonae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2
-
 Pelophylax lessonae 17alpha-hydroxypregnenolone + A + H2O
-
 ?
1.14.14.19 progesterone + AH2 + O2
-
 Pelophylax lessonae 17alpha-hydroxyprogesterone + A + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.19 cytochrome P450 17alpha-hydroxylase/C17,20-lyase
-
 Pelophylax lessonae
1.14.14.19 P450c17
-
 Pelophylax lessonae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.14.19 24
-
 assay at Pelophylax lessonae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.14.19 7.4
-
 assay at Pelophylax lessonae