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Literature summary extracted from

  • Zhou, L.Y.; Wang, D.S.; Senthilkumaran, B.; Yoshikuni, M.; Shibata, Y.; Kobayashi, T.; Sudhakumari, C.C.; Nagahama, Y.
    Cloning, expression and characterization of three types of 17beta-hydroxysteroid dehydrogenases from the Nile tilapia, Oreochromis niloticus (2005), J. Mol. Endocrinol., 35, 103-116.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.51 isozyme DNA and amino acid sequence determination and analysis, tissue-specific expression and phylogenetic analysis, expression of tissue-specific isozymes 17beta-HSD1 and 17beta-HSD8 in Escherichia coli and in HEK-293 cells Oreochromis niloticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 additional information Oreochromis niloticus the enzyme plays a role in gonadal steroidogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Oreochromis niloticus
-
 Nile tilapia, tissue-specific isozymes 17beta-HSD1 and 17beta-HSD8
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 brain isozyme 17beta-HSD8 Oreochromis niloticus
-
1.1.1.51 gill isozyme 17beta-HSD8 Oreochromis niloticus
-
1.1.1.51 gonad isozyme 17beta-HSD8 Oreochromis niloticus
-
1.1.1.51 heart isozyme 17beta-HSD8 Oreochromis niloticus
-
1.1.1.51 intestine isozyme 17beta-HSD8 Oreochromis niloticus
-
1.1.1.51 kidney isozyme 17beta-HSD8 Oreochromis niloticus
-
1.1.1.51 liver isozyme 17beta-HSD8 Oreochromis niloticus
-
1.1.1.51 additional information three tissue-specific isozymes, 17beta-HSD1 and 17beta-HSD8 Oreochromis niloticus
-
1.1.1.51 muscle isozyme 17beta-HSD8 Oreochromis niloticus
-
1.1.1.51 ovary isozyme 17beta-HSD1, predominantly Oreochromis niloticus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 androstenedione + NADPH + H+ isozymes 17beta-HSD1 and 17beta-HSD8 Oreochromis niloticus testosterone + NADP+
-
 r
1.1.1.51 additional information the enzyme plays a role in gonadal steroidogenesis Oreochromis niloticus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-hydroxysteroid dehydrogenase
-
 Oreochromis niloticus
1.1.1.51 More cf. 1.1.1.62 Oreochromis niloticus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.51 37
-
 assay at Oreochromis niloticus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.51 7.4
-
 assay at Oreochromis niloticus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADP+
-
 Oreochromis niloticus
1.1.1.51 NADPH
-
 Oreochromis niloticus