Literature summary extracted from

Lee, B.; Bauer, H.; Melchers, J.; Ruppert, T.; Rattray, L.; Yardley, V.; Davioud-Charvet, E.; Krauth-Siegel, R.L.
Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate (2005), J. Med. Chem., 48, 7400-7410.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.8.1.12	(1E)-1-(2-chlorophenyl)penta-1,4-dien-3-one	0.1 mM, irreversible inhibition	Trypanosoma cruzi
1.8.1.12	(4E)-5-(2-chlorophenyl)-N,N,2,2-tetramethyl-3-oxopent-4-en-1-aminium chloride	0.1 mM, reversible inhibition	Trypanosoma cruzi
1.8.1.12	(4E)-5-(2-chlorophenyl)-N,N-dimethyl-3-oxopent-4-en-1-aminium chloride	0.1 mM, irreversible inhibition	Trypanosoma cruzi
1.8.1.12	1-[(4E)-5-(2-chlorophenyl)-3-oxopent-4-en-1-yl]piperidinium chloride	0.1 mM, irreversible inhibition	Trypanosoma cruzi
1.8.1.12	4-(2-chlorobenzyl)cyclopent-2-en-1-one	0.1 mM, reversible inhibition	Trypanosoma cruzi
1.8.1.12	4-[(4E)-5-(2-chlorophenyl)-3-oxopent-4-en-1-yl]morpholin-4-ium chloride	0.1 mM, irreversible inhibition	Trypanosoma cruzi

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.1.12	Trypanosoma cruzi	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.1.12	trypanothione disulfide + NADPH	-	Trypanosoma cruzi	trypanothione + NADP+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.8.1.12	TR	-	Trypanosoma cruzi
1.8.1.12	trypanothione reductase	-	Trypanosoma cruzi

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.8.1.12	NADPH	-	Trypanosoma cruzi

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Release 2023.1 (January 2023)