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Literature summary extracted from
- Dihydroxydocosahexaenoic acids of the neuroprotectin D family: synthesis, structure, and inhibition of human 5-lipoxygenase (2006), J. Lipid Res., 47, 2462-2474.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.34 | 10,17(S)-dihydroxydocosahexaenoic acid | IC50: 0.017 mM | Homo sapiens |  |
| 1.13.11.34 | 7,17(S)-dihydroxydocosahexaenoic acid | IC50: 0.007 mM | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.34 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.34 | arachidonate + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.13.11.34 | 5LOX-1 | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.13.11.34 | 0.007 | - |
IC50: 0.007 mM | Homo sapiens | 7,17(S)-dihydroxydocosahexaenoic acid | |
| 1.13.11.34 | 0.017 | - |
IC50: 0.017 mM | Homo sapiens | 10,17(S)-dihydroxydocosahexaenoic acid | |
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