EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.22 | 3'-anthraniloyl-dGTP | - |
Haemophilus influenzae | |
2.7.4.22 | 3'-anthraniloyl-dGTP | - |
Escherichia coli | |
2.7.4.22 | 3'-anthraniloyl-dGTP | - |
Neisseria meningitidis | |
2.7.4.22 | 3'-anthraniloyl-dGTP | strong activator | Streptococcus pneumoniae | |
2.7.4.22 | 3'-anthraniloyl-dGTP | strong activator | Bacillus subtilis | |
2.7.4.22 | 7-deaza-dGTP | - |
Haemophilus influenzae | |
2.7.4.22 | 7-deaza-dGTP | - |
Streptococcus pneumoniae | |
2.7.4.22 | 7-deaza-dGTP | - |
Bacillus subtilis | |
2.7.4.22 | 7-deaza-dGTP | - |
Escherichia coli | |
2.7.4.22 | 7-deaza-dGTP | - |
Neisseria meningitidis | |
2.7.4.22 | dGTP | - |
Haemophilus influenzae | |
2.7.4.22 | dGTP | - |
Streptococcus pneumoniae | |
2.7.4.22 | dGTP | - |
Bacillus subtilis | |
2.7.4.22 | dGTP | - |
Escherichia coli | |
2.7.4.22 | dGTP | - |
Neisseria meningitidis | |
2.7.4.22 | GMP | - |
Haemophilus influenzae | |
2.7.4.22 | GMP | not activating | Streptococcus pneumoniae | |
2.7.4.22 | GMP | not activating | Bacillus subtilis | |
2.7.4.22 | GMP-PNP | - |
Streptococcus pneumoniae | |
2.7.4.22 | GMP-PNP | - |
Bacillus subtilis | |
2.7.4.22 | GMP-PNP | - |
Escherichia coli | |
2.7.4.22 | GMP-PNP | GMP-PNP | Haemophilus influenzae | |
2.7.4.22 | GMP-PNP | less activating | Neisseria meningitidis | |
2.7.4.22 | GTP | 0.5 mM | Staphylococcus aureus | |
2.7.4.22 | GTP | 0.5 mM | Enterococcus faecalis | |
2.7.4.22 | GTP | 0.5 mM | Streptococcus pneumoniae | |
2.7.4.22 | GTP | at 0.5 mM | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.4.22 | GTP | 0.5 mM, independent of the concentrations of Mg2+ | Haemophilus influenzae | |
2.7.4.22 | GTP | 0.5 mM, more activating at low concentrations of ATP | Bacillus subtilis | |
2.7.4.22 | GTP | 0.5 mM, reverses the inhibition of excess UMP, it increases the affinity for ATP | Escherichia coli | |
2.7.4.22 | GTP | 0.5 mM, reverses the inhibition of excess UMP, it increases the affinity for ATP | Neisseria meningitidis | |
2.7.4.22 | ITP | - |
Haemophilus influenzae | |
2.7.4.22 | ITP | - |
Streptococcus pneumoniae | |
2.7.4.22 | ITP | - |
Bacillus subtilis | |
2.7.4.22 | ITP | - |
Escherichia coli | |
2.7.4.22 | ITP | - |
Neisseria meningitidis | |
2.7.4.22 | additional information | GMP is not activating | Neisseria meningitidis | |
2.7.4.22 | XTP | - |
Haemophilus influenzae | |
2.7.4.22 | XTP | - |
Streptococcus pneumoniae | |
2.7.4.22 | XTP | - |
Bacillus subtilis | |
2.7.4.22 | XTP | - |
Escherichia coli | |
2.7.4.22 | XTP | - |
Neisseria meningitidis |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.4.22 | expression in Escherichia coli | Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | expression in Escherichia coli | Staphylococcus aureus |
2.7.4.22 | expression in Escherichia coli | Haemophilus influenzae |
2.7.4.22 | expression in Escherichia coli | Enterococcus faecalis |
2.7.4.22 | expression in Escherichia coli | Streptococcus pneumoniae |
2.7.4.22 | expression in Escherichia coli | Neisseria meningitidis |
2.7.4.22 | expression in Escherichia coli, site directed mutagenesis | Bacillus subtilis |
2.7.4.22 | expression in Escherichia coli, site directed mutagenesis | Escherichia coli |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.4.22 | N137A | Tm 10°C lower than wild type, loss of cooperativity with ATP, sensitive to activation by GTP | Bacillus subtilis |
2.7.4.22 | N140A | cooperative inhibition by GTP and UTP is altered, lower thermodynamic stability | Escherichia coli |
2.7.4.22 | T135A | Tm 10°C lower than wild type, loss of cooperativity with ATP, increase in Km for UMP, sensitive to activation by GTP | Bacillus subtilis |
2.7.4.22 | T135A/N137A | Tm 10°C lower than wild type, at pH 7.4 in 50 mM Tris irreversible inactivated within hours | Bacillus subtilis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.22 | 5-bromo-UMP | not inhibitory | Enterococcus faecalis | |
2.7.4.22 | 5-bromo-UMP | not inhibitory | Escherichia coli | |
2.7.4.22 | 5-bromo-UMP | not inhibitory | Haemophilus influenzae | |
2.7.4.22 | 5-bromo-UMP | not inhibitory | Streptococcus pneumoniae | |
2.7.4.22 | 5-Bromo-UTP | - |
Bacillus subtilis | |
2.7.4.22 | 5-Bromo-UTP | less inhibitory than UTP | Enterococcus faecalis | |
2.7.4.22 | 5-Bromo-UTP | less inhibitory than UTP | Escherichia coli | |
2.7.4.22 | 5-Bromo-UTP | less inhibitory than UTP | Haemophilus influenzae | |
2.7.4.22 | 5-Bromo-UTP | more inhibitory than UTP | Streptococcus pneumoniae | |
2.7.4.22 | 5-fluoro-UTP | - |
Bacillus subtilis | |
2.7.4.22 | 5-fluoro-UTP | like UTP | Enterococcus faecalis | |
2.7.4.22 | 5-fluoro-UTP | like UTP | Escherichia coli | |
2.7.4.22 | 5-fluoro-UTP | like UTP | Haemophilus influenzae | |
2.7.4.22 | 5-fluoro-UTP | less inhibitory than UTP | Streptococcus pneumoniae | |
2.7.4.22 | 5-iodo-UMP | not inhibitory | Enterococcus faecalis | |
2.7.4.22 | 5-iodo-UMP | not inhibitory | Escherichia coli | |
2.7.4.22 | 5-iodo-UMP | not inhibitory | Haemophilus influenzae | |
2.7.4.22 | 5-iodo-UMP | not inhibitory | Streptococcus pneumoniae | |
2.7.4.22 | 5-iodo-UTP | - |
Bacillus subtilis | |
2.7.4.22 | 5-iodo-UTP | less inhibitory than UTP | Enterococcus faecalis | |
2.7.4.22 | 5-iodo-UTP | less inhibitory than UTP | Escherichia coli | |
2.7.4.22 | 5-iodo-UTP | less inhibitory than UTP | Haemophilus influenzae | |
2.7.4.22 | 5-iodo-UTP | more inhibitory than UTP | Streptococcus pneumoniae | |
2.7.4.22 | dUTP | five times weaker than UTP | Bacillus subtilis | |
2.7.4.22 | dUTP | five times weaker than UTP | Escherichia coli | |
2.7.4.22 | dUTP | five times weaker than UTP | Haemophilus influenzae | |
2.7.4.22 | dUTP | five times weaker than UTP | Streptococcus pneumoniae | |
2.7.4.22 | TTP | not inhibitory | Bacillus subtilis | |
2.7.4.22 | TTP | not inhibitory | Enterococcus faecalis | |
2.7.4.22 | TTP | not inhibitory | Escherichia coli | |
2.7.4.22 | TTP | not inhibitory | Haemophilus influenzae | |
2.7.4.22 | TTP | not inhibitory | Streptococcus pneumoniae | |
2.7.4.22 | UMP | - |
Bacillus subtilis | |
2.7.4.22 | UMP | excess UMP at high concentrations, UTP deminishes this inhibition | Escherichia coli | |
2.7.4.22 | UMP | excess UMP at high concentrations, UTP deminishes this inhibition | Haemophilus influenzae | |
2.7.4.22 | UMP | excess UMP at high concentrations, UTP deminishes this inhibition | Neisseria meningitidis | |
2.7.4.22 | UMP | excess UMP at high concentrations | Streptococcus pneumoniae | |
2.7.4.22 | UTP | inhibition not affected by Mg2+ and UMP | Bacillus subtilis | |
2.7.4.22 | UTP | inhibition not affected by Mg2+ and UMP | Enterococcus faecalis | |
2.7.4.22 | UTP | 0.25 mM, 0.5 mM, GTP, UMP and high concentrations of Mg2+ protects against inhibition by UTP, decreases the affinity for ATP, inhibition only without Mg2+ | Escherichia coli | |
2.7.4.22 | UTP | 0.25 mM, 0.5 mM, GTP, UMP and high concentrations of Mg2+ protects against inhibition by UTP, decreases the affinity for ATP, inhibition only without Mg2+ | Haemophilus influenzae | |
2.7.4.22 | UTP | 0.25 mM, 0.5 mM, UMP protects against inhibition by UTP, decreases the affinity for ATP, inhibition only without Mg2+ | Neisseria meningitidis | |
2.7.4.22 | UTP | - |
Streptococcus pneumoniae |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.22 | 0.0087 | - |
UMP | in presence of 2.0 mM ATP without GTP | Neisseria meningitidis | |
2.7.4.22 | 0.01 | - |
UMP | in presence of 2.0 mM ATP without GTP | Bacillus subtilis | |
2.7.4.22 | 0.0156 | - |
UMP | in presence of 10.0 mM ATP without GTP | Neisseria meningitidis | |
2.7.4.22 | 0.0274 | - |
UMP | in presence of 2.0 mM ATP and 0.5 mM GTP | Bacillus subtilis | |
2.7.4.22 | 0.04 | - |
UMP | in presence of 1.0 mM ATP and 0.5 mM GTP | Haemophilus influenzae | |
2.7.4.22 | 0.04 | - |
UMP | in presence of 1.0 mM ATP without GTP | Haemophilus influenzae | |
2.7.4.22 | 0.046 | - |
UMP | in presence of 2.0 mM ATP without GTP | Escherichia coli | |
2.7.4.22 | 0.047 | - |
UMP | in presence of 0.2 mM ATP and 0.5 mM GTP | Escherichia coli | |
2.7.4.22 | 0.0492 | - |
UMP | in presence of 0.2 mM ATP without GTP | Escherichia coli | |
2.7.4.22 | 0.05 | - |
UMP | in presence of 12.0 mM ATP and 0.5 mM GTP | Haemophilus influenzae | |
2.7.4.22 | 0.051 | - |
UMP | in presence of 2.0 mM ATP and 0.5 mM GTP | Escherichia coli | |
2.7.4.22 | 0.0574 | - |
UMP | in presence of 10.0 mM ATP and 0.5 mM GTP | Neisseria meningitidis | |
2.7.4.22 | 0.0997 | - |
UMP | in presence of 2.0 mM ATP and 0.5 mM GTP | Streptococcus pneumoniae | |
2.7.4.22 | 0.1 | - |
UMP | in presence of 12.0 mM ATP without GTP | Haemophilus influenzae | |
2.7.4.22 | 0.1 | - |
UMP | in presence of 2.0 mM ATP and 0.5 mM GTP | Neisseria meningitidis | |
2.7.4.22 | 0.1056 | - |
UMP | in presence of 30 mM ATP and 0.5 mM GTP | Streptococcus pneumoniae | |
2.7.4.22 | 0.131 | - |
UMP | in presence of 30 mM ATP without GTP | Bacillus subtilis | |
2.7.4.22 | 0.15 | - |
ATP | in presence of 1.0 mM UMP without GTP | Escherichia coli | |
2.7.4.22 | 0.15 | - |
UMP | in presence of 30 mM ATP without GTP | Streptococcus pneumoniae | |
2.7.4.22 | 0.155 | - |
UMP | in presence of 30 mM ATP and 0.5 mM GTP | Bacillus subtilis | |
2.7.4.22 | 0.2 | - |
ATP | in presence of 1.0 mM UMP and 0.5 mM GTP | Escherichia coli | |
2.7.4.22 | 0.207 | - |
UMP | in presence of 2.0 mM ATP, 0.5 mM UTP and 0.5 mM GTP | Escherichia coli | |
2.7.4.22 | 0.23 | - |
ATP | in presence of 0.1 mM UMP without GTP | Escherichia coli | |
2.7.4.22 | 0.26 | - |
ATP | in presence of 2.0 mM ATP, 0.5 mM UTP and 0.5 mM GTP | Escherichia coli | |
2.7.4.22 | 0.27 | - |
ATP | in presence of 0.1 mM UMP and 0.5 mM GTP | Escherichia coli | |
2.7.4.22 | 0.46 | - |
ATP | in presence of 0.1 mM UMP and 0.5 mM GTP | Haemophilus influenzae | |
2.7.4.22 | 0.6 | - |
ATP | in presence of 1.0 mM UMP and 0.5 mM GTP | Haemophilus influenzae | |
2.7.4.22 | 0.77 | - |
ATP | in presence of 2.0 mM ATP and 0.5 mM UTP | Escherichia coli | |
2.7.4.22 | 0.83 | - |
ATP | in presence of 0.05 mM UMP and 0.5 mM GTP | Neisseria meningitidis | |
2.7.4.22 | 0.9 | - |
ATP | in presence of 1.0 mM UMP and 0.5 mM GTP | Staphylococcus aureus | |
2.7.4.22 | 0.92 | - |
ATP | in presence of 1.0 mM UMP and 0.5 mM GTP | Streptococcus pneumoniae | |
2.7.4.22 | 0.93 | - |
ATP | in presence of 0.1 mM UMP and 0.5 mM GTP | Bacillus subtilis | |
2.7.4.22 | 1 | - |
ATP | in presence of 0.5 mM UTP | Escherichia coli | |
2.7.4.22 | 1.57 | - |
ATP | in presence of 0.1 mM UMP without GTP | Haemophilus influenzae | |
2.7.4.22 | 1.62 | - |
ATP | in presence of 1.0 mM UMP without GTP | Haemophilus influenzae | |
2.7.4.22 | 1.69 | - |
UMP | in presence of 2.0 mM ATP and 0.5 mM UTP | Escherichia coli | |
2.7.4.22 | 1.79 | - |
ATP | in presence of 1.0 mM UMP and 0.5 mM GTP | Bacillus subtilis | |
2.7.4.22 | 1.98 | - |
ATP | in presence of 1.0 mM UMP and 0.5 mM GTP | Neisseria meningitidis | |
2.7.4.22 | 2.64 | - |
ATP | in presence of 1.0 mM UMP without GTP | Staphylococcus aureus | |
2.7.4.22 | 2.98 | - |
ATP | in presence of 0.05 mM UMP without GTP | Neisseria meningitidis | |
2.7.4.22 | 3.22 | - |
ATP | in presence of 1.0 mM UMP without GTP | Neisseria meningitidis | |
2.7.4.22 | 4.5 | - |
ATP | in presence of 0.5 mM UTP | Haemophilus influenzae | |
2.7.4.22 | 9.8 | - |
ATP | in presence of 1.0 mM UMP without GTP | Streptococcus pneumoniae | |
2.7.4.22 | 10.4 | - |
ATP | in presence of 0.1 mM UMP without GTP | Bacillus subtilis | |
2.7.4.22 | 14.5 | - |
ATP | in presence of 1.0 mM UMP without GTP | Bacillus subtilis | |
2.7.4.22 | 22.2 | - |
UMP | in presence of 2.0 mM ATP without GTP | Streptococcus pneumoniae | |
2.7.4.22 | 30 | - |
ATP | in presence of 0.5 mM UTP | Bacillus subtilis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.22 | Mg2+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.4.22 | Mg2+ | - |
Staphylococcus aureus | |
2.7.4.22 | Mg2+ | - |
Haemophilus influenzae | |
2.7.4.22 | Mg2+ | - |
Enterococcus faecalis | |
2.7.4.22 | Mg2+ | - |
Streptococcus pneumoniae | |
2.7.4.22 | Mg2+ | - |
Bacillus subtilis | |
2.7.4.22 | Mg2+ | - |
Escherichia coli | |
2.7.4.22 | Mg2+ | - |
Neisseria meningitidis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.4.22 | Bacillus subtilis | O31749 | - |
- |
2.7.4.22 | Enterococcus faecalis | - |
- |
- |
2.7.4.22 | Escherichia coli | A7ZWB7 | - |
- |
2.7.4.22 | Haemophilus influenzae | - |
- |
- |
2.7.4.22 | Neisseria meningitidis | P65932 | - |
- |
2.7.4.22 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
2.7.4.22 | Staphylococcus aureus | - |
- |
- |
2.7.4.22 | Streptococcus pneumoniae | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.4.22 | of the recombinant protein by affinity chromatography | Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | of the recombinant protein by affinity chromatography | Staphylococcus aureus |
2.7.4.22 | of the recombinant protein by affinity chromatography | Enterococcus faecalis |
2.7.4.22 | of the recombinant protein by affinity chromatography | Streptococcus pneumoniae |
2.7.4.22 | of the recombinant protein by affinity chromatography | Bacillus subtilis |
2.7.4.22 | of the recombinant protein by affinity chromatography | Neisseria meningitidis |
2.7.4.22 | of the recombinant protein by affinity chromatography, no difference in activity compared to the wild type | Haemophilus influenzae |
2.7.4.22 | of the recombinant protein by affinity chromatography, no difference in activity compared to the wild type | Escherichia coli |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.4.22 | 1.7 | - |
at 2.0 mM ATP, without GTP | Enterococcus faecalis |
2.7.4.22 | 2.7 | - |
at 2.0 mM ATP, without GTP | Bacillus subtilis |
2.7.4.22 | 3.7 | - |
at 2.0 mM ATP, without GTP | Streptococcus pneumoniae |
2.7.4.22 | 4.6 | - |
at 2.0 mM ATP, without GTP | Staphylococcus aureus |
2.7.4.22 | 5.1 | - |
activity dependent of concentrations of ATP, at 2.0 mM ATP, without GTP | Neisseria meningitidis |
2.7.4.22 | 9.1 | - |
activity independent of concentrations of ATP, at 2.0 mM ATP, without GTP | Haemophilus influenzae |
2.7.4.22 | 9.1 | - |
at 8.0 mM ATP, without GTP | Enterococcus faecalis |
2.7.4.22 | 9.7 | - |
at 2.0 mM ATP, with 0.5 mM GTP | Enterococcus faecalis |
2.7.4.22 | 10.2 | - |
at 8.0 mM ATP, with 0.5 mM GTP | Neisseria meningitidis |
2.7.4.22 | 11.3 | - |
at 8.0 mM ATP, without GTP | Neisseria meningitidis |
2.7.4.22 | 11.8 | - |
at 8.0 mM ATP, without GTP | Haemophilus influenzae |
2.7.4.22 | 12.8 | - |
at 8.0 mM ATP, without GTP | Staphylococcus aureus |
2.7.4.22 | 18.1 | - |
at 8.0 mM ATP, without GTP | Bacillus subtilis |
2.7.4.22 | 19.4 | - |
at 8.0 mM ATP, with 0.5 mM GTP | Enterococcus faecalis |
2.7.4.22 | 23.5 | - |
at 2.0 mM ATP, with 0.5 mM GTP | Staphylococcus aureus |
2.7.4.22 | 23.6 | - |
at 8.0 mM ATP, with 0.5 mM GTP | Staphylococcus aureus |
2.7.4.22 | 26.1 | - |
at 2.0 mM ATP, without GTP | Escherichia coli |
2.7.4.22 | 28.1 | - |
at 8.0 mM ATP, without GTP | Escherichia coli |
2.7.4.22 | 28.6 | - |
at 2.0 mM ATP, with 0.5 mM GTP | Bacillus subtilis |
2.7.4.22 | 38.9 | - |
at 8.0 mM ATP, without GTP | Streptococcus pneumoniae |
2.7.4.22 | 39.1 | - |
at 8.0 mM ATP, with 0.5 mM GTP | Bacillus subtilis |
2.7.4.22 | 46.8 | - |
activity independent of concentrations of ATP, at 2.0 mM ATP, without GTP | Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | 47.5 | - |
at 8.0 mM ATP, without GTP | Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | 52.8 | - |
at 2.0 mM ATP, with 0.5 mM GTP | Haemophilus influenzae |
2.7.4.22 | 57.7 | - |
at 2.0 mM ATP, with 0.5 mM GTP | Neisseria meningitidis |
2.7.4.22 | 60.5 | - |
at 8.0 mM ATP, with 0.5 mM GTP | Haemophilus influenzae |
2.7.4.22 | 65.9 | - |
at 2.0 mM ATP, with 0.5 mM GTP | Escherichia coli |
2.7.4.22 | 68.5 | - |
at 2.0 mM ATP, with 0.5 mM GTP | Streptococcus pneumoniae |
2.7.4.22 | 71.1 | - |
at 8.0 mM ATP, with 0.5 mM GTP | Escherichia coli |
2.7.4.22 | 87.4 | - |
at 8.0 mM ATP, with 0.5 mM GTP | Streptococcus pneumoniae |
2.7.4.22 | 124.2 | - |
at 8.0 mM ATP, with 0.5 mM GTP | Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | 134.3 | - |
at 2.0 mM ATP, with 0.5 mM GTP | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.22 | ATP + UMP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ADP + UDP | - |
r | |
2.7.4.22 | ATP + UMP | - |
Staphylococcus aureus | ADP + UDP | - |
r | |
2.7.4.22 | ATP + UMP | - |
Haemophilus influenzae | ADP + UDP | - |
r | |
2.7.4.22 | ATP + UMP | - |
Enterococcus faecalis | ADP + UDP | - |
r | |
2.7.4.22 | ATP + UMP | - |
Streptococcus pneumoniae | ADP + UDP | - |
r | |
2.7.4.22 | ATP + UMP | - |
Bacillus subtilis | ADP + UDP | - |
r | |
2.7.4.22 | ATP + UMP | - |
Escherichia coli | ADP + UDP | - |
r | |
2.7.4.22 | ATP + UMP | - |
Neisseria meningitidis | ADP + UDP | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.4.22 | hexamer | gel filtration | Staphylococcus aureus |
2.7.4.22 | hexamer | gel filtration | Enterococcus faecalis |
2.7.4.22 | hexamer | gel filtration | Streptococcus pneumoniae |
2.7.4.22 | hexamer | gel filtration | Bacillus subtilis |
2.7.4.22 | hexamer | gel filtration | Neisseria meningitidis |
2.7.4.22 | hexamer | gel permeation | Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | hexamer | gel permeation | Haemophilus influenzae |
2.7.4.22 | hexamer | gel permeation | Escherichia coli |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.4.22 | ATP:UMP phosphotransferase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | ATP:UMP phosphotransferase | - |
Staphylococcus aureus |
2.7.4.22 | ATP:UMP phosphotransferase | - |
Haemophilus influenzae |
2.7.4.22 | ATP:UMP phosphotransferase | - |
Enterococcus faecalis |
2.7.4.22 | ATP:UMP phosphotransferase | - |
Streptococcus pneumoniae |
2.7.4.22 | ATP:UMP phosphotransferase | - |
Bacillus subtilis |
2.7.4.22 | ATP:UMP phosphotransferase | - |
Escherichia coli |
2.7.4.22 | ATP:UMP phosphotransferase | - |
Neisseria meningitidis |
2.7.4.22 | UMP kinase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | UMP kinase | - |
Staphylococcus aureus |
2.7.4.22 | UMP kinase | - |
Haemophilus influenzae |
2.7.4.22 | UMP kinase | - |
Enterococcus faecalis |
2.7.4.22 | UMP kinase | - |
Streptococcus pneumoniae |
2.7.4.22 | UMP kinase | - |
Bacillus subtilis |
2.7.4.22 | UMP kinase | - |
Escherichia coli |
2.7.4.22 | UMP kinase | - |
Neisseria meningitidis |
2.7.4.22 | uridine monophosphate kinase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | uridine monophosphate kinase | - |
Staphylococcus aureus |
2.7.4.22 | uridine monophosphate kinase | - |
Haemophilus influenzae |
2.7.4.22 | uridine monophosphate kinase | - |
Enterococcus faecalis |
2.7.4.22 | uridine monophosphate kinase | - |
Streptococcus pneumoniae |
2.7.4.22 | uridine monophosphate kinase | - |
Bacillus subtilis |
2.7.4.22 | uridine monophosphate kinase | - |
Neisseria meningitidis |
2.7.4.22 | uridylate kinase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
2.7.4.22 | uridylate kinase | - |
Staphylococcus aureus |
2.7.4.22 | uridylate kinase | - |
Haemophilus influenzae |
2.7.4.22 | uridylate kinase | - |
Enterococcus faecalis |
2.7.4.22 | uridylate kinase | - |
Streptococcus pneumoniae |
2.7.4.22 | uridylate kinase | - |
Bacillus subtilis |
2.7.4.22 | uridylate kinase | - |
Neisseria meningitidis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.22 | 0.11 | - |
UMP | at 2.0 mM ATP, without GTP | Neisseria meningitidis | |
2.7.4.22 | 0.17 | - |
UMP | at 12 mM ATP, without GTP | Haemophilus influenzae | |
2.7.4.22 | 0.23 | - |
UMP | at 10 mM ATP, without GTP | Neisseria meningitidis | |
2.7.4.22 | 0.31 | - |
UMP | at 1.0 mM ATP, without GTP | Haemophilus influenzae | |
2.7.4.22 | 0.44 | - |
UMP | at 2.0 mM ATP, without GTP | Escherichia coli | |
2.7.4.22 | 0.6 | - |
UMP | at 2.0 mM ATP, without GTP | Escherichia coli | |
2.7.4.22 | 0.66 | - |
UMP | at 2.0 mM ATP, without GTP, no inhibition at 30 mM ATP | Bacillus subtilis | |
2.7.4.22 | 4.4 | - |
UMP | at 2.0 mM ATP, without GTP | Streptococcus pneumoniae |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.4.22 | 0.01 | - |
at 0.05 mM UMP, UMP protects for inhibition by Mg2+ free UTP | Neisseria meningitidis | UTP | |
2.7.4.22 | 0.13 | - |
at 0.2 mM UMP, UMP protects for inhibition by Mg2+ free UTP | Neisseria meningitidis | UTP |