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Literature summary extracted from

  • Wu, J.; Woodard, R.W.
    New insights into the evolutionary links relating to the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase subfamilies (2006), J. Biol. Chem., 281, 4042-4048.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.54 expressed in Escherichia coli Bacillus subtilis
2.5.1.54 expressed in Escherichia coli Porphyromonas gingivalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.54 chorismate IC50: 1 mM Bacillus subtilis
2.5.1.54 prephenate IC50: 0.1 mM Bacillus subtilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.54 0.1415
-
 phosphoenolpyruvate at 37°C Bacillus subtilis
2.5.1.54 1.4
-
 D-erythrose 4-phosphate at 37°C Bacillus subtilis
2.5.1.54 2.724
-
 phosphoenolpyruvate at 37°C Porphyromonas gingivalis
2.5.1.54 3.638
-
 D-erythrose 4-phosphate at 37°C Porphyromonas gingivalis

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.54 Bacillus subtilis
-
-
-
2.5.1.54 Porphyromonas gingivalis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.54
-
 Bacillus subtilis
2.5.1.54
-
 Porphyromonas gingivalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.54 phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
 Bacillus subtilis 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
 ?
2.5.1.54 phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
 Porphyromonas gingivalis 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.54 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
-
 Bacillus subtilis
2.5.1.54 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
-
 Porphyromonas gingivalis
2.5.1.54 AroA(Q)
-
 Bacillus subtilis
2.5.1.54 AroA(Q)
-
 Porphyromonas gingivalis
2.5.1.54 DAHPS
-
 Bacillus subtilis
2.5.1.54 DAHPS
-
 Porphyromonas gingivalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.54 9
-
-
 Bacillus subtilis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.54 0.1
-
 IC50: 0.1 mM Bacillus subtilis prephenate
2.5.1.54 1
-
 IC50: 1 mM Bacillus subtilis chorismate