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Literature summary extracted from

  • MirAfzali, Z.; Leipprandt, J.R.; McCracken, J.L.; DeWitt, D.L.
    Topography of the prostaglandin endoperoxide H2 synthase-2 in membranes (2006), J. Biol. Chem., 281, 28354-28364.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.1 into a baculoviral vector for expression in Sf-21 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.99.1 C299S/C526S mutant, relative activity: 70% Homo sapiens
1.14.99.1 F59C mutant, relative activity: 50% Homo sapiens
1.14.99.1 F66C mutant, relative activity: 50% Homo sapiens
1.14.99.1 F84C mutant, relative activity: 50% Homo sapiens
1.14.99.1 G83C mutant, relative activity: 35% Homo sapiens
1.14.99.1 H75C mutant, relative activity: 70% Homo sapiens
1.14.99.1 I63C mutant, relative activity: 70% Homo sapiens
1.14.99.1 I77C mutant, relative activity: 60% Homo sapiens
1.14.99.1 K64C mutant, relative activity: 70% Homo sapiens
1.14.99.1 L60C mutant, relative activity: 70% Homo sapiens
1.14.99.1 L65C mutant, relative activity: 70% Homo sapiens
1.14.99.1 L67C mutant, relative activity: 40% Homo sapiens
1.14.99.1 L78C mutant, relative activity: 30% Homo sapiens
1.14.99.1 N72C mutant, relative activity: 60% Homo sapiens
1.14.99.1 N86C mutant, relative activity: 50% Homo sapiens
1.14.99.1 N89C mutant, relative activity: 30% Homo sapiens
1.14.99.1 N90C mutant, relative activity: 20% Homo sapiens
1.14.99.1 R62C mutant, relative activity: 50% Homo sapiens
1.14.99.1 T61C mutant, relative activity: 60% Homo sapiens
1.14.99.1 T73C mutant, relative activity: 40% Homo sapiens
1.14.99.1 V74C mutant, relative activity: 60% Homo sapiens
1.14.99.1 V87C mutant, relative activity: 30% Homo sapiens
1.14.99.1 V88C mutant, relative activity: 30% Homo sapiens
1.14.99.1 W85C mutant, relative activity: 10% Homo sapiens
1.14.99.1 Y76C mutant, relative activity: 70% Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.99.1 membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.1 arachidonate + AH2 + O2 Homo sapiens
-
prostaglandin H2 + A + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.99.1 using nickel affinity chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.1 arachidonate + AH2 + O2
-
Homo sapiens prostaglandin H2 + A + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.1 COX-2
-
Homo sapiens
1.14.99.1 cyclooxygenase-2
-
Homo sapiens
1.14.99.1 PGHS-2
-
Homo sapiens
1.14.99.1 prostaglandin endoperoxide H2 synthase-2
-
Homo sapiens