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Literature summary extracted from

  • Liu, S.; Knafels, J.D.; Chang, J.S.; Waszak, G.A.; Baldwin, E.T.; Deibel, M.R.; Thomsen, D.R.; Homa, F.L.; Wells, P.A.; Tory, M.C.; Poorman, R.A.; Gao, H.; Qiu, X.; Seddon, A.P.
    Crystal structure of the herpes simplex virus 1 DNA polymerase (2006), J. Biol. Chem., 281, 18193-18200.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.7 a fusion protein consisting of bacterial maltose-binding protein and full-length HSV 1 POL is constructed with either one factor Xa cleavage site at the linker region or with a second factor Xa site right after Asn-42 of HSV POL. The maltose-binding protein-HSV POL fusion protein is expressed in a baculovirus/insect cell system Human alphaherpesvirus 1

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.7 hanging drop vapor diffusion, crystal structure at 2.7 A resolution, crystals of HSV POL belong to space group P212121, with typical unit cell dimensions of a = 103.9 A, b = 125.6 A, c = 220.6 A Human alphaherpesvirus 1

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.7 4-oxo-dihydroquinoline binds at the polymerase active site interacting non-covalently with both the polymerase and the DNA duplex Human alphaherpesvirus 1

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Human alphaherpesvirus 1
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Synonyms

EC Number Synonyms Comment Organism
2.7.7.7 HSV 1 POL
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 Human alphaherpesvirus 1