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Literature summary extracted from

  • Golczak, M.; Imanishi, Y.; Kuksa, V.; Maeda, T.; Kubota, R.; Palczewski, K.
    Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle (2005), J. Biol. Chem., 280, 42263-42273.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.135 inducible expression of LRAT in HEK-293S cells Mus musculus
2.3.1.135 inducible expression of LRAT in HEK-293S cells Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.135 retinylamine
-
 Bos taurus
2.3.1.135 retinylamine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.135 additional information Bos taurus LRAT plays an essential role in the regeneration of visual chromophore as well as in the metabolism of vitamin A, and is responsible for amidation of retinylamine, a potent and selective inhibitor of the retinoid cycle and 11-cis-retinal biosynthesis ?
-
 ?
2.3.1.135 additional information Mus musculus LRAT plays an essential role in the regeneration of visual chromophore as well as in the metabolism of vitaminA, and is responsible for amidation of retinylamine, a potent and selective inhibitor of the retinoid cycle and 11-cis-retinal biosynthesis ?
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol Bos taurus LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A 2-acylglycerophosphocholine + all-trans-retinyl ester
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol Mus musculus LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A 2-acylglycerophosphocholine + retinyl ester
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinylamine Bos taurus
-
 2-acylglycerophosphocholine + all-trans-retinyl acylamide
-
 ?
2.3.1.135 phosphatidylcholine + retinylamine Mus musculus
-
 2-acylglycerophosphocholine + fatty acid N-retinylamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.135 Bos taurus
-
-
-
2.3.1.135 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.135 eye
-
 Mus musculus
-
2.3.1.135 eye
-
 Bos taurus
-
2.3.1.135 liver
-
 Mus musculus
-
2.3.1.135 retinal pigment epithelium
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.135 additional information LRAT plays an essential role in the regeneration of visual chromophore as well as in the metabolism of vitamin A, and is responsible for amidation of retinylamine, a potent and selective inhibitor of the retinoid cycle and 11-cis-retinal biosynthesis Bos taurus ?
-
 ?
2.3.1.135 additional information LRAT plays an essential role in the regeneration of visual chromophore as well as in the metabolism of vitaminA, and is responsible for amidation of retinylamine, a potent and selective inhibitor of the retinoid cycle and 11-cis-retinal biosynthesis Mus musculus ?
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A Bos taurus 2-acylglycerophosphocholine + all-trans-retinyl ester
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol LRAT catalyzes the transfer of an acyl group, chain length C14-C18, from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A Bos taurus 2-acylglycerophosphocholine + all-trans-retinyl ester product identification ?
2.3.1.135 phosphatidylcholine + all-trans-retinol LRAT catalyzes the transfer of an acyl group from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A Mus musculus 2-acylglycerophosphocholine + retinyl ester
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol LRAT catalyzes the transfer of an acyl group, chain length C14-C18, from the sn-1 position of phosphatidylcholine to all-trans-retinol, vitamin A Mus musculus 2-acylglycerophosphocholine + retinyl ester product identification ?
2.3.1.135 phosphatidylcholine + all-trans-retinylamine
-
 Bos taurus 2-acylglycerophosphocholine + all-trans-retinyl acylamide
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinylamine
-
 Bos taurus 2-acylglycerophosphocholine + fatty acid-N-all-trans-retinyl amide product identification ?
2.3.1.135 phosphatidylcholine + retinylamine
-
 Mus musculus 2-acylglycerophosphocholine + fatty acid N-retinylamide
-
 ?
2.3.1.135 phosphatidylcholine + retinylamine
-
 Mus musculus 2-acylglycerophosphocholine + fatty acid N-retinylamide product identification ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.135 lecithin:retinol acyltransferase
-
 Mus musculus
2.3.1.135 lecithin:retinol acyltransferase
-
 Bos taurus
2.3.1.135 LRAT
-
 Mus musculus
2.3.1.135 LRAT
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.135 37
-
 assay at Mus musculus
2.3.1.135 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.135 7.5
-
 assay at Mus musculus
2.3.1.135 7.5
-
 assay at Bos taurus