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Literature summary extracted from

  • Eastman, R.T.; White, J.; Hucke, O.; Bauer, K.; Yokoyama, K.; Nallan, L.; Chakrabarti, D.; Verlinde, C.L.; Gelb, M.H.; Rathod, P.K.; Van Voorhis, W.C.
    Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum (2005), J. Biol. Chem., 280, 13554-13559.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.58 Y837C the mutant is resistant to the PFT inhibitor BMS-388891 Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.58 BMS-388891
-
 Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.58 0.00032
-
 farnesyl diphosphate mutant enzyme Y837C Plasmodium falciparum
2.5.1.58 0.00064
-
 farnesyl diphosphate wild type enzyme Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.58 Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.58 farnesyl diphosphate + protein-cysteine
-
 Plasmodium falciparum diphosphate + S-farnesyl protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.58 PFT
-
 Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.58 0.00000022
-
 BMS-388891 wild type enzyme Plasmodium falciparum
2.5.1.58 0.0000012
-
 BMS-388891 mutant enzyme Y837C Plasmodium falciparum